Endocrine effects of naloxone-induced opiate receptor blockade.
Endocrine effects of naloxone-induced opiate receptor blockade.
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纳洛酮诱导的阿片受体阻断的内分泌影响。
DOI：
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发表时间：
1980
影响因子：
5.8
通讯作者：
A. A. Varner
中科院分区：
文献类型：
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作者：
John E. Morley;N. Baranetsky;TERENCE D. Wingert;Harold E. Carlson;J. Hershman;S. Melmed;SEYMOUR R. Levin;KAY R. Jamison;Richard Weitzman;R. J. Chang;A. A. Varner
为了检测阿片受体阻断剂对人体激素释放的影响，我们给8名正常受试者静脉注射10 mg纳洛酮，并将结果与生理盐水输注后的结果进行比较。纳洛酮使血清皮质醇（P < 0.01）、LH（P <0.01）、FSH（P < 0.05）和胰岛素（P <0.05）水平升高，但不改变血清GH、PRL、TSH、精氨酸加压素、胰高血糖素、T3或T4。纳洛酮e对2例活动性肢端肥大症患者的GH水平或6例原发性甲状腺功能减退症患者的TSH水平无影响。在动态垂体功能试验中，纳洛酮可降低精氨酸对GH的反应（P < 0.05），但不影响PRL的反应，纳洛酮可增强TRH对PRL的反应（P < 0.025），但不影响TSH的反应。纳洛酮没有显着改变GH或PRL反应L-多巴。纳洛酮可增强胃镜检查应激引起的血清皮质醇升高，但不改变GH或PRL的反应。结论：纳洛酮能显著增加葡萄糖反应面积。
To test the effect of opiate receptor blockade on hormone release in man, we administered 10 mg naloxone iv to eight normal subjects and compared the results with those found after saline infusion. Naloxone produced a rise in serum cortisol (P < 0.01), LH (P < 0.01), FSH (P < 0.05), and insulin (P < 0.05) levels but did not alter serum GH, PRL, TSH, arginine vasopressin, glucagon, T3, or T4. Naloxon e had no effect on GH levels in two subjects with active acromegaly or on TSH levels i n six subjects with primary hypothyroidism. In dynamic pituitary function testing, naloxone diminished the GH response to arginine (P < 0.05) without altering the PRL response; naloxone augmented the PRL response to TRH (P < 0.025) without affecting the TSH response. Naloxone did not significantly alter GH or PRL response to L-dopa. Naloxone enhanced the increment in serum cortisol induced by the stress of gastroscopy without changing the GH or PRL response. Naloxone increased glucose response areas (P < 0.05) after an iv gl...