Serum osteoprotegerin and its relationship with bone mineral density and markers of bone turnover
Serum osteoprotegerin and its relationship with bone mineral density and markers of bone turnover
复制标题
DOI：
10.1007/s00198-004-1699-x
复制
发表时间：
2005-04-01
影响因子：
4
通讯作者：
Sigurdsson, G
中科院分区：
文献类型：
--
作者：
Indridason, OS;Franzson, L;Sigurdsson, G
简介：本研究的目的是比较骨保护素（OPG）与BMD和血清骨标志物骨钙素（OC）、胶原交联（CTX）和抗酒石酸酸性磷酸酶5 b（TRACP-5 b）之间的年龄相关差异。研究方法：数据来源于冰岛雷克雅未克地区30至85岁社区居民随机抽样的骨骼健康横断面研究。所有受试者都进行了全身、髋关节和腰椎BMD测量（DXA），提供了血液样本，并回答了关于药物和病史的完整问卷。我们使用斯皮尔曼相关系数、偏相关和多变量线性回归来评估相关性。男性和女性分别进行分析。结果：在2年内邀请的2，310名受试者中，有1，630名参与。在排除患有影响骨代谢的疾病和药物的个体后。517名女性（年龄56.1 +/- 16.9岁）和491名男性（年龄58.7 +/- 14.9岁）仍用于分析。OPG随着年龄的增长而稳步增加，无性别差异。在女性中，所有部位的BMD在50岁后稳步下降。在男性中，BMD在70岁之前保持相对稳定，之后显著下降。在控制了年龄、BMI和其他混杂变量后，男性OPG与全身BMD仅呈边缘性正相关（P=0.10），但女性OPG与全身BMD的相关性不显著。在多变量模型中，OPG与TRACP-5 b（P=0.002）呈负相关，与女性OC（P=0.007）、OC/TRACP-5 b（P=0.001）和OC/CTX（P=0.02）比值呈正相关。在男性中，多变量模型显示OPG与OC（P=0.05）和OC/TRACP-5 b（P < 0.009）呈正相关。结论：我们的结论是，血清OPG水平与有利于骨形成的骨转换标志物谱相关，这表明OPG可能对年龄相关的骨质流失具有保护作用。需要进行纵向研究来解决这一问题。
Introduction: The purpose of this study was to compare age-related differences in osteoprotegerin (OPG) in relationship with BMD and the serum bone markers osteocalcin (OC), collagen crosslinks (CTX), and tartrate-resistant acid phosphatase 5b (TRACP-5b). Methods: Data were derived from a cross-sectional study on bone health in a random sample of community-dwelling adults aged 30 to 85 years in the Reykjavik area in Iceland. All subjects had whole body, hip, and lumbar spine BMD measured (by DXA), gave blood samples, and answered a thorough questionnaire on medications and medical history. We assessed relationships using the Spearman correlation coefficient, partial correlation, and multivariable linear regression. Men and women were analyzed separately. Results: Of 2,310 subjects invited over 2 years, 1,630 participated. After excluding individuals with diseases and medications affecting bone metabolism. 517 women (age 56.1 +/- 16.9 years) and 491 men (age 58.7 +/- 14.9 years) remained for analysis. OPG increased steadily with age in both genders without a gender difference. In women, BMD at all sites declined steadily after age 50. In men, BMD remained relatively stable until age 70, after which it declined significantly. After controlling for age, BMI, and other confounding variables, OPG showed only a borderline positive relationship with whole body BMD in men (P=0.10), but the relationship was nonsignificant in women. In multivariable models, OPG was inversely related to TRACP-5b (P=0.002) and positively with OC (P=0.007), the OC/TRACP-5b (P=0.001) and OC/CTX (P=0.02) ratios in women. Among men, multivariable models showed a positive association between OPG and OC (P=0.05) and OC/TRACP-5b (P < 0.009). Conclusions: We conclude that serum OPG levels are associated with a profile of bone turnover markers favoring bone formation, suggesting that OPG may be protective against age-related bone loss. Longitudinal studies are needed to address that issue.