MULTIPLE SCLEROSIS - VITAMIN D AND CALCIUM AS ENVIRONMENTAL DETERMINANTS OF PREVALENCE (A VIEWPOINT) .1. SUNLIGHT, DIETARY FACTORS AND EPIDEMIOLOGY
MULTIPLE SCLEROSIS - VITAMIN D AND CALCIUM AS ENVIRONMENTAL DETERMINANTS OF PREVALENCE (A VIEWPOINT) .1. SUNLIGHT, DIETARY FACTORS AND EPIDEMIOLOGY
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DOI：
10.1080/00207237408709630
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发表时间：
1974-01-01
影响因子：
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通讯作者：
GOLDBERG, P
中科院分区：
文献类型：
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作者：
GOLDBERG, P
根据维生素D假说，多发性硬化症中的脱髓鞘是由于脑发育期间产生的异常脂质组成和结构导致的髓鞘分解。观察到的异常（改变的脂质浓度和脂肪酸谱）被认为是在管理髓鞘脂质合成和膜组装的酶的缺陷的结果。这种酶缺乏症是遗传性的，被认为是由于在髓鞘形成和生长迅速的时期，主要是在青春期，维生素D和钙的供应不足而发生的。如果该理论被证明是正确的，那么在青春期通过饮食补充维生素D和钙来抑制这种疾病是可能的。
According to the vitamin D hypothesis, demyelination in multiple sclerosis results from a breakdown of myelin due to abnormal lipid composition and structure, produced during the period of brain development. The observed abnormalities (altered lipid concentrations and fatty acid profiles) are viewed as a consequence of deficiencies in enzymes that govern myelin lipid synthesis and membrane assembly. The enzyme deficiencies, genetic in origin, are proposed to occur because of inadequate supplies of vitamin D and calcium at times of rapid myelination and growth, mainly in adolescence. If the theory proves to be correct, it may be possible to suppress the disease by dietary supplementation with vitamin D and calcium during puberty.