A survey of children's preferences for influenza vaccine attributes
A survey of children's preferences for influenza vaccine attributes
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DOI：
10.1016/j.vaccine.2011.04.018
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发表时间：
2011-06-10
期刊：
影响因子：
5.5
通讯作者：
Mahadevia, Parthiv J.
中科院分区：
文献类型：
--
作者：
Flood, Emuella M.;Ryan, Kellie J.;Mahadevia, Parthiv J.
背景：虽然疾病预防控制中心建议6个月及以上的儿童每年接种流感疫苗，但疫苗接种率仍然不理想。对于2岁及以上的健康美国儿童，流感疫苗可分别作为肌肉注射（TIV）或鼻内喷雾（LAIV）。关于儿童的经历和对流感疫苗特性的偏好知之甚少。目的：了解儿童对流感疫苗属性的偏好及其相对重要性。方法：对8-12岁的儿童进行定量网络调查，从美国人口的常设在线小组中抽样。儿童按年龄、性别和父母的流感疫苗接种行为分层。该调查包括确定儿童对流感疫苗属性的偏好的问题，包括有效性、常见副作用的可能性和给药方式。它包括联合（权衡）问题，在这些问题中，儿童在选择两种具有不同特征的流感疫苗时权衡不同的属性。调查了幼儿对连词题的理解能力和完成能力。结果：544名儿童完成调查，回复率为37%。儿童最常选择有效性作为疫苗最重要的属性，其次是给药方式（分别为45%和31%）。当被问及他们更愿意接受流感疫苗作为“注射”或“鼻喷雾剂”时，大多数人（69%）更喜欢鼻喷雾剂。对儿童完成联合调查能力的评估表明，85%的样本能够完成联合任务。对联合反应的分析表明，给药方式和疗效对偏好的影响最大，相对重要性分别为40.5%和30.6%。在代表LAIV和TIV的有效性、副作用和其他特征的疫苗类型的直接比较中，79%的儿童更喜欢LAIV样类型。结论：样本中的儿童对流感疫苗的属性有一致的看法，并认为疫苗的效力和给药方式是重要的。儿童可被告知流感预防的参与者，并可被纳入有关流感疫苗接种的讨论。(C) 2011 Elsevier Ltd.版权所有。
Background: While annual influenza vaccination is recommended by the CDC for children 6 months and older, vaccination rates remain suboptimal. For healthy, US children 2 years of age and older, influenza vaccine is available as an intramuscular injection (TIV) or an intranasal spray (LAIV), respectively. Little is known about children's experiences and preferences for influenza vaccine attributes.Objective: To examine preferences for influenza vaccine attributes and their relative importance among children.Methods: A quantitative web-survey was administered to children aged 8-12 years sampled from a standing online panel representative of the US population. Children were stratified by age, gender and parent's influenza vaccination behavior. The survey included questions to ascertain children's preferences for influenza vaccine attributes, including efficacy, chance of common side effects, and mode of administration. It included conjoint (trade-off) questions in which children traded-off different attributes in their choice between two influenza vaccines with differing features. We also surveyed children's comprehension of and ability to complete the conjoint questions.Results: 544 children completed the survey (response rate 37%). Children most frequently selected efficacy as the most important vaccine attribute followed by mode of administration (45% and 31%, respectively). When asked for their preference to receive influenza vaccine as a "shot" or a "nose spray", the majority (69%) preferred the nose spray. An evaluation of children's ability to complete the conjoint survey demonstrated that 85% of the sample was able to complete the conjoint tasks. Analysis of the conjoint responses demonstrated that mode of administration and efficacy had the greatest impact on preferences, with a relative importance of 40.5% and 30.6%, respectively. In a direct comparison of vaccine profiles representing the efficacy, side effects, and other characteristics of LAIV and TIV, 79% of children preferred the LAIV-like profile.Conclusion: Children in the sample had consistent opinions regarding influenza vaccine attributes and consider vaccine efficacy and mode of administration to be important. Children can be informed participants in influenza prevention and can be included in discussions regarding influenza vaccination. (C) 2011 Elsevier Ltd. All rights reserved.