IMMUNOREGULATORY CIRCUITS AMONG T-CELL SETS - IDENTIFICATION OF A SUB-POPULATION OF T-HELPER CELLS THAT INDUCES FEEDBACK INHIBITION
IMMUNOREGULATORY CIRCUITS AMONG T-CELL SETS - IDENTIFICATION OF A SUB-POPULATION OF T-HELPER CELLS THAT INDUCES FEEDBACK INHIBITION
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DOI：
10.1084/jem.148.4.871
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发表时间：
1978-01-01
影响因子：
15.3
通讯作者：
GERSHON, RK
中科院分区：
文献类型：
--
作者：
CANTOR, H;HUGENBERGER, J;GERSHON, RK
纯化的Lyl[小鼠]细胞诱导其他T[胸腺来源]细胞组发挥有效的反馈抑制活性，并且这种T-T相互作用在调节体内免疫反应中发挥重要作用。大约 2/3 的 Ly1 细胞还表达 Qal 表面表型（Lyl:Qal+ 细胞）。 Lyl:Qal+ 细胞负责诱导反馈抑制和来自 Lyl:Qal+ 细胞的信号，Lyl:Qal- 细胞是 B [骨髓来源] 细胞最佳形成抗体所必需的。
Purified Lyl [mouse] cells induce other T[thymus derived]-cell sets to exert potent feedback inhibitory activity and this T-T interaction plays an important role in regulating in vivo immune responses. Approximately 2/3 of Ly1 cells also express the Qal surface phenotype (Lyl:Qal+ cells). Lyl:Qal+ cells are responsible for induction of feedback inhibition and signals from Lyl:Qal+ cells and Lyl:Qal- cells are required for optimal formation of antibody by B [bone marrow derived] cells.