Irbesartan increased PPARγ activity in vivo in white adipose tissue of atherosclerotic mice and improved adipose tissue dysfunction
Irbesartan increased PPARγ activity in vivo in white adipose tissue of atherosclerotic mice and improved adipose tissue dysfunction
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DOI：
10.1016/j.bbrc.2011.02.007
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发表时间：
2011-03-04
影响因子：
3.1
通讯作者：
Horiuchi, Masatsugu
中科院分区：
文献类型：
--
作者：
Iwai, Masaru;Kanno, Harumi;Horiuchi, Masatsugu
使用动脉粥样硬化模型小鼠，研究了AT（1）受体阻断剂厄贝沙坦对脂肪组织功能障碍的PPAR γ激动作用。对9周龄的成年雄性载脂蛋白E缺陷（ApoEKO）小鼠给予高胆固醇饮食（HCD）（含或不含厄贝沙坦），剂量为50 mg/kg/天，持续4周。伊贝沙坦可降低附睾和腹膜后脂肪组织的重量，而不改变摄食量或体重。厄贝沙坦治疗增加了白色脂肪组织中PPAR γ的表达和脂肪组织制备的核提取物中PPAR γ的DNA结合活性。伊贝沙坦还能增加脂联素、瘦素和胰岛素受体的表达。这些结果表明，厄贝沙坦诱导激活的过氧化物酶体增殖物激活受体γ和改善脂肪组织功能障碍，包括胰岛素抵抗。(C)2011 Elsevier Inc. All rights reserved.
The effect of the PPAR gamma agonistic action of an AT(1) receptor blocker, irbesartan, on adipose tissue dysfunction was explored using atherosclerotic model mice. Adult male apolipoprotein E-deficient (ApoEKO) mice at 9 weeks of age were treated with a high-cholesterol diet (HCD) with or without irbesartan at a dose of 50 mg/kg/day for 4 weeks. The weight of epididymal and retroperitoneal adipose tissue was decreased by irbesartan without changing food intake or body weight. Treatment with irbesartan increased the expression of PPAR gamma in white adipose tissue and the DNA-binding activity of PPAR gamma in nuclear extract prepared from adipose tissue. The expression of adiponectin, leptin and insulin receptor was also increased by irbesartan. These results suggest that irbesartan induced activation of PPAR gamma and improved adipose tissue dysfunction including insulin resistance. (C) 2011 Elsevier Inc. All rights reserved.