Physical forces make rete ridges in oral mucosa
Physical forces make rete ridges in oral mucosa
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物理力在口腔粘膜中形成网状脊
DOI：
10.1016/j.mehy.2013.07.005
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发表时间：
2013-11-01
影响因子：
4.7
通讯作者：
He, Sangang
中科院分区：
文献类型：
--
作者：
Xiong, Xuepeng;Wu, Tianfu;He, Sangang
Rete嵴在表皮中具有重要的功能，但目前的组织工程口腔黏膜或皮肤等效物通常缺乏这种结构。为了在口腔黏膜等效物中再生网状嵴结构，我们首先试图弄清楚网状嵴是如何在口腔黏膜中形成的，初步研究揭示了机械应力诱发网状嵴的形态发生。在本文中，我们假设rete嵴的形态发生是由物理力引起的，并通过角质细胞分裂产生的内部推力进行，在此过程中，活化的ERK和PC级联，伴随着释放的MMPs生长因子共同作用，诱导角质细胞增殖，这些细胞分裂产生内力。它们不仅推动角质细胞干细胞和祖细胞向相反方向迁移，还反过来激活ERK和PC级联，同时，被激活的MMPs降解固有层的ECM，在这些内部推力和固有层的重塑作用下，网状脊逐渐形成。这一假设为我们通过模拟网状嵴的形态发生，在组织工程口腔黏膜或皮肤等效物中再生网状嵴结构提供了可能性。爱思唯尔有限公司版权所有版权所有。
Rete ridge has important functions in the epidermis, but the current tissue engineered oral mucosa or skin equivalents are generally lack of this structure. To regenerate a rete ridge structure in the oral mucosa equivalents, we firstly attempted to make clear how rete ridge is formed in the oral mucosa and the preliminary study disclosed the mechanical stress evoked the morphogenesis of rete ridge. In this paper, we make a hypothesis that the morphogenesis of rete ridge is elicited by the physical forces and proceed with the internal pushing forces derived from the keratinocyte division, among these process, the activated ERK and PC cascades, accompanied with the MMPs liberated growth factors are working together to induce the keratinocyte proliferation, these cell divisions produced internal forces, which not only push the keratinocyte stem cells and progenitor cells to migrate in the contrary directions but also in turn to activate the ERK and PC cascades, meanwhile, the activated MMPs degrade the ECM of lamina propria, under these internal pushing forces and the remodeling of lamina propria, rete ridge is gradually formed. This hypothesis gives us the possibility to regenerate the rete ridge structure in the tissue engineered oral mucosa or skin equivalents through simulating the morphogenesis of rete ridge. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.