Hypereosinophilic syndrome associated with occlusive coronary thrombosis and right ventricular thrombus
Hypereosinophilic syndrome associated with occlusive coronary thrombosis and right ventricular thrombus
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DOI：
10.1111/j.1440-1827.2007.02202.x
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发表时间：
2008-02-01
影响因子：
2.2
通讯作者：
Asada, Yujiro
中科院分区：
文献类型：
--
作者：
Sato, Yuichiro;Fukunaga, Takashi;Asada, Yujiro
一例44岁的HES男性患者在右心室内出现大血栓以及多处闭塞性冠状动脉血栓，死于心力衰竭。尸检显示右心室内的大血栓与嗜酸性心内膜炎有关。此外，在回旋支和右冠状动脉中形成闭塞性血栓，壁中有嗜酸性粒细胞浸润。研究结果表明冠状动脉血栓形成和嗜酸性粒细胞增多之间存在因果关系。据作者所知，这是第一份记录HES患者冠状动脉血栓形成的临床和组织学结果的报告。
A 44-year-old man with HES who developed a large thrombus in the right ventricle as well as multiple occlusive coronary thrombi died of cardiac failure. Autopsy showed that a large thrombus in the right ventricle was associated with eosinophilic endocarditis. In addition, an occlusive thrombus formed in the circumflex and right coronary arteries with eosinophilic infiltrate in the walls. The findings suggest a causal relationship between coronary thrombosis and eosinophilia. To the authors' knowledge this is the first report to document the clinical and histological findings of coronary thrombosis in a patient with HES.