Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.
Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.
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DOI：
10.1016/j.cell.2016.12.032
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发表时间：
2017-01-12
期刊：
影响因子：
64.5
通讯作者：
Inoue T
中科院分区：
文献类型：
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作者：
Phua SC;Chiba S;Suzuki M;Su E;Roberson EC;Pusapati GV;Schurmans S;Setou M;Rohatgi R;Reiter JF;Ikegami K;Inoue T
The life cycle of a primary cilium begins in quiescence and ends prior to mitosis. In quiescent cells, primary cilium insulates itself from contiguous dynamic membrane processes on the cell surface to function as a stable signaling apparatus. Here, we demonstrate that basal restriction of ciliary structure dynamics is established by cilia-enriched phosphoinositide 5-phosphatase, Inpp5e. Growth induction displaces ciliary Inpp5e and accumulates phosphatidylinositol 4,5-bisphosphate to distal cilia. This triggers otherwise forbidden actin polymerization in primary cilia, which excises cilia tips in a process we call cilia decapitation. Whilst cilia disassembly is traditionally thought to occur solely through resorption, we show that an acute loss of IFT-B through cilia decapitation precedes resorption. Finally, we propose that cilia decapitation induces mitogenic signaling and constitutes a molecular link between the cilia life cycle and cell-division cycle. This newly defined ciliary mechanism may find significance in cell proliferation control during normal development and cancer.
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DOI：
10.1073/pnas.1210916109
发表时间：
2012-11-27
影响因子：
11.1
作者：
Humbert, Melissa C.;Weihbrecht, Katie;Seo, Seongjin
通讯作者：
Seo, Seongjin
DOI：
10.1073/pnas.1101657108
发表时间：
2011-03-15
影响因子：
11.1
作者：
Monje, Michelle;Mitra, Siddhartha S.;Beachy, Philip A.
通讯作者：
Beachy, Philip A.
DOI：
10.1083/jcb.201009001
发表时间：
2011-04-04
期刊：
The Journal of cell biology
影响因子：
--
作者：
Francis SS;Sfakianos J;Lo B;Mellman I
通讯作者：
Mellman I
初级纤毛通过 Lkb1 调节 mTORC1 活性和细胞大小。
影响因子：
21.3
作者：
Boehlke, Christopher;Kotsis, Fruzsina;Patel, Vishal;Braeg, Simone;Voelker, Henriette;Bredt, Saskia;Beyer, Theresa;Janusch, Heike;Hamann, Christoph;Goedel, Markus;Mueller, Klaus;Herbst, Martin;Hornung, Miriam;Doerken, Mara;Koettgen, Michael;Nitschke, Roland;Igarashi, Peter;Walz, Gerd;Kuehn, E. Wolfgang
通讯作者：
Kuehn, E. Wolfgang
影响因子：
21.3
作者：
通讯作者：
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