PALISADED ENCAPSULATED NEUROMA (SOLITARY CIRCUMSCRIBED NEUROMA) - A CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY
PALISADED ENCAPSULATED NEUROMA (SOLITARY CIRCUMSCRIBED NEUROMA) - A CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY
复制标题
DOI：
10.1097/00000372-199404000-00002
复制
发表时间：
1994-04-01
影响因子：
1.1
通讯作者：
MEGAHED, M
中科院分区：
文献类型：
--
作者：
MEGAHED, M
虽然栅栏状包裹性神经瘤在20多年前首次被描述，但很少受到关注。我们目前的临床，组织病理学和免疫组化特征的10例这种实体。病例进行了研究，通过常规光镜检查和免疫组化使用抗生物素蛋白-生物素-过氧化物酶技术。临床信息和随访数据来自医院记录。皮损为孤立性、无症状、皮肤色丘疹，位于患者面部，年龄37 ~ 66岁（平均52岁）。男女比例为1：1。所有患者均无von Recklinghausen病，切除后无一例复发。组织学上，肿瘤边界清楚，主要位于真皮。它们被包裹，由梭形细胞组成，呈束状交错排列。肿瘤细胞S-100蛋白阳性。包膜由扁平、细长的细胞组成，显示上皮膜抗原（EMA）阳性。
Although palisaded encapsulated neuroma was first described over 20 years ago, it has received little attention. We present the clinical, histopathologic, and immunohistochemical features of 10 cases of this entity. The cases were studied by routine light-microscopic examination and immunohistochemistry using the avidin-biotin-peroxidase technique. Clinical information and follow-up data were obtained from the hospital records. The lesions were solitary, asymptomatic, skin-colored papules that were located on the faces of patients who ranged in aged from 37 to 66 years (average, 52 years). The female to male ratio was 1:1. None of the patients had von Recklinghausen's disease, and none of the lesions recurred after excision. Histopathologically, the tumors were well circumscribed and situated predominantly in the dermis. They were encapsulated and composed of spindle cells arranged in interlacing fascicles. The tumor cells were positive for S-100 protein. The capsule was composed of flattened, elongated cells that showed positivity for epithelial membrane antigen (EMA).