Selenonium ylides: synthesis, characterization, and applications to photo-induced cyclopropanation reactions
Selenonium ylides: synthesis, characterization, and applications to photo-induced cyclopropanation reactions
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DOI：
10.1007/s43630-021-00155-2
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发表时间：
2022-01
影响因子：
3.1
通讯作者：
E. Yamaguchi;Hisamori Inagawa;A. Itoh
中科院分区：
文献类型：
--
作者：
E. Yamaguchi;Hisamori Inagawa;A. Itoh
卡宾是合成各种复杂分子的重要的高活性中间体。它们现在是有机化学中不可或缺的化学物种，并且经常用于药物发现化学中合成复杂化合物。一般而言，卡宾是通过过渡金属催化剂和重氮化合物的组合或通过重氮化合物的分解反应来合成的。本文报道了一种新的硒叶立德在可见光下光化学生成卡宾的研究进展。总的来说，这种使用C，Se-硒鎓叶立德的光化学卡宾生成方法不需要催化剂，操作简单，并且能够与烯烃进行高效的环丙烷化反应。
Carbenes are important and highly reactive intermediates for the synthesis of various complex molecules. They are now an indispensable chemical species in organic chemistry and are used frequently to synthesize complex compounds in drug discovery chemistry. In general, carbenes are synthesized by a combination of transition metal catalysts and diazo compounds or by the decomposition reactions of diazo compounds. This paper reports the development of the visible light for the photochemical generation of carbenes from a novelC,Se-selenonium ylide. Overall, this photochemical carbene generation method usingC,Se-selenonium ylide does not require a catalyst, is simple to perform, and enables highly efficient cyclopropanation reactions with alkenes.Graphical abstract