Increased hsp22 RNA levels in Drosophila lines genetically selected for increased longevity
Increased hsp22 RNA levels in Drosophila lines genetically selected for increased longevity
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DOI：
10.1093/gerona/55.11.b552
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发表时间：
2000-11-01
影响因子：
5.1
通讯作者：
Tower, J
中科院分区：
文献类型：
--
作者：
Kurapati, R;Passananti, HB;Tower, J
小热休克蛋白（hsp）基因hsp22和hsp23的rna在果蝇衰老过程中被诱导，这表明这些基因可能在晚年具有特定的功能。为了确定hsp22和hsp23基因的表达是否可能与寿命相关，在一组5个近交的“O”系和5个匹配的对照“B”系中，分析了这些基因和其他基因的RNA水平，这些基因被遗传选择为延长寿命。O系和B系对照核糖体蛋白基因rp49和AP3/RpPO RNA水平相似。相比之下，hsp22 RNA水平在所有5个O系中比在所有5个B系中高2 - 10倍，而hsp23表现出较小但显著的增加。因此，增加的hsp22和hsp23 RNA水平与遗传选择的O系寿命延长和抗逆性增强相关。
RNAs for the small heat shock protein (hsp) genes hsp22 and hsp23 are induced during Drosophila aging, suggesting that these genes might have specific functions at late ages. To determine if hsp22 and hsp23 gene expression might correlate with life span, RNA levels for these and additional genes were analyzed throughout the adult life span in a set of five outbred "O" lines, which have been genetically selected for increased longevity, and in five matched control "B" lines. Control ribosomal protein genes rp49 and AP3/RpPO RNA levels were similar in O and B lines. In contrast, hsp22 RNA levels were twofold-tenfold higher in all five O lines relative to all five B lines, while hsp23 exhibited a smaller but significant increase. Thus increased hsp22 and hsp23 RNA levels correlate with the increased life span and increased stress resistance of the genetically selected O lines.