Investigation of acoustic radiation force for radio-protecting normal tissues during radiation therapy.
Investigation of acoustic radiation force for radio-protecting normal tissues during radiation therapy.
复制标题
放射治疗期间正常组织辐射防护的声辐射力研究。
DOI：
10.1109/iembs.2009.5335044
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Yu,Yan
中科院分区：
文献类型：
--
作者：
Yan,Kaiguo;Wachsberger,Phyllis;Yu,Yan
放射治疗（Radiation therapy）是医学上使用电离辐射作为癌症治疗的一部分，以根除恶性细胞。正常组织耐受性目前是一个主要的剂量限制因素。由于分子氧在放射损伤中起着关键作用，我们提出了一种新的方法，即利用声辐射力（ARF）来抑制正常组织的氧合，以达到保护正常组织并提高其对放射治疗耐受性的目的。本文研究了ARF对组织氧合的影响。皮下组织和肿瘤进行了比较研究。已经使用鼠模型进行了实验。初步结果表明，ARF能有效抑制正常组织氧合，同时对肿瘤氧合的影响甚微。正在进行进一步的研究，以表征不同超声参数（频率、强度、超声脉冲持续时间等）下氧气变化的时间过程，以达到最佳控制组织氧合的目的。
Radiation therapy (radiotherapy) is the medical use of ionizing radiation as part of cancer treatment to erradicate malignant cells. Normal tissue tolerance is currently a major dose-limiting factor. As molecular oxygen plays a critical role in creating the radiation damage, we propose a novel approach, that is, the use of acoustic radiation force (ARF) to suppress the normal tissue oxygenation, for the purpose of protecting the normal tissue and increasing its tolerance during radiotherapy. This paper investigated the effects of ARF on tissue oxygenation. Both subcutaneous tissue and tumor were studied for comparison. Experiments have been carried out using a murine model. Preliminary results showed that ARF can effectively suppress normal tissue oxygenation, and at the same time had negligible effect on the tumor oxygenation. Further investigation is ongoing to characterize the time course of oxygen changes with different ultrasound parameters (frequency, intensity, ultrasound pulse duration, etc.), for the purpose of optimal control of tissue oxygenation.