On the identification of individual level pleiotropic, pure direct, and principal stratum direct effects without cross world assumptions
On the identification of individual level pleiotropic, pure direct, and principal stratum direct effects without cross world assumptions
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DOI：
10.1111/sjos.12464
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发表时间：
2020-08-18
影响因子：
1
通讯作者：
VanderWeele, Tyler J.
中科院分区：
文献类型：
--
作者：
Zaidi, Jaffer M.;VanderWeele, Tyler J.
自然直接和主要阶层直接影响的分析在统计学和因果推断中有争议的历史，因为这些影响通常被认为是不可检验的跨世界独立性或图形假设。这篇文章表明，存在的个人层面的自然直接和主要阶层的直接影响，可以确定没有跨世界的独立性假设。我们还定义了一种新类型的因果效应，称为多效性，这是基因组学的兴趣，并提供经验条件，以检测这样的效果。我们的结果适用于所有类型的分布有关的中介和结果。
The analysis of natural direct and principal stratum direct effects has a controversial history in statistics and causal inference as these effects are commonly identified with either untestable cross world independence or graphical assumptions. This article demonstrates that the presence of individual level natural direct and principal stratum direct effects can be identified without cross world independence assumptions. We also define a new type of causal effect, called pleiotropy, that is of interest in genomics, and provide empirical conditions to detect such an effect as well. Our results are applicable for all types of distributions concerning the mediator and outcome.