Neuroinflammation and subarachnoid hemorrhage: a revised look at the literature.
Neuroinflammation and subarachnoid hemorrhage: a revised look at the literature.
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DOI：
10.53388/crc20220014
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发表时间：
2022-01-01
期刊：
影响因子：
--
通讯作者：
Lucke-Wold, Brandon
中科院分区：
文献类型：
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作者：
Sriram, Sai;Cutler, Christopher;Lucke-Wold, Brandon
动脉瘤性蛛网膜下腔出血的一个关键问题是神经炎症。神经炎性疾病易导致动脉瘤的形成和破裂。动脉瘤破裂后血液分解产物也可能导致神经炎症。最近的证据表明，永久性的神经炎症可能导致血管痉挛和脑积水。靶向神经炎症是预防后续神经后遗症的一种新机制。在这篇综述中，我们强调了动脉瘤形成的病理生理学，破裂后的神经炎性激增，包括所涉及的细胞因子，并最终与临床相关。在最后一节中，我们将关注临床前数据和进一步发现的新途径。这篇论文将成为临床医生和科研人员的有用资源。
A key topic for aneurysmal subarachnoid hemorrhage is neuroinflammation. Neuroinflammation can predispose to aneurysm formation and rupture. Neuroinflammation can also result from the blood breakdown products after aneurysm rupture. Recent evidence has shown that perpetual neuroinflammation can contribute to vasospasm and hydrocephalus. Targeting neuroinflammation is a novel mechanism for preventing subsequent neurologic sequalae. In this review, we highlight the pathophysiology of aneurysm formation, the neuroinflammatory surge after rupture including the involved cytokines, and ultimately tie in the contributory clinical relevance. In the last sections, we look at the pre-clinical data and novel avenues for further discovery. This paper will be a useful resource to both the clinician and scientific investigator.