A rare case of myxoid liposarcoma of the adult foot diagnosed using fine needle aspiration cytology (FNAC)
A rare case of myxoid liposarcoma of the adult foot diagnosed using fine needle aspiration cytology (FNAC)
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DOI：
10.2147/plmi.s72042
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发表时间：
2015-01-01
影响因子：
0.2
通讯作者：
Naito, Zenya
中科院分区：
文献类型：
--
作者：
Kure, Shoko;Peng, Wei-Xia;Naito, Zenya
脂肪肉瘤被归类为软组织肉瘤，最常见于成年期的下肢，但很少发生在足部。我们报告一位63岁的男性，在足部发生一罕见的原发性黏液样脂肪肉瘤，经细针穿刺细胞学检查诊断。病人来我院就诊，有10年的病史，左外踝有一个缓慢生长的肿块。在体格检查时，发现60 mm x 60 mm的肿块柔软而有弹性，导致活动性差，无疼痛。肿块的磁共振成像显示T1加权像上的高信号强度和T2加权像上不均匀的高信号强度，没有脂肪抑制。由于体格检查和影像学检查，肿块被怀疑是脂肪瘤或腱鞘囊肿。然而，细针穿刺发现非典型的小、圆、短梭形细胞或泡沫细胞伴粘液样背景，提示粘液样脂肪肉瘤。采用开放性活检的组织学显示非典型梭形和星状细胞增殖，在毛细血管丰富和粘液样背景中有少量泡沫状成脂细胞。非典型脂肪母细胞S-100呈弱阳性。这些结果与粘液样脂肪肉瘤一致。患者接受了肿块切除术治疗。脂肪肉瘤被认为是第二常见的软组织肉瘤。它通常涉及下肢，特别是大腿，并且在成人足部非常罕见。我们的病例是一个罕见的足部黏液样脂肪肉瘤，术前用细针穿刺诊断。
Liposarcoma is categorized as a soft tissue sarcoma that most commonly appears in the lower extremities during adulthood, but rarely in the feet. We present a rare case of a primary myxoid liposarcoma in the foot of a 63-year-old man that was diagnosed by fine needle aspiration cytology (FNAC). The patient presented to our hospital with a 10-year history of a slow-growing mass on the left lateral ankle. On physical examination, the 60 mm x 60 mm mass, was found to be soft and elastic, causing poor mobility without pain. Magnetic resonance imaging of the mass revealed high signal intensity on T1-weighted images and heterogeneously high signal intensity on T2-weighted images without fat suppression. As a result of the physical examination and imaging, the mass was suspected to be a lipoma or ganglion cyst. However, the FNAC procedure revealed atypical small, round, short spindle cells, or foamy cells with a myxoid background, suggesting myxoid liposarcoma. Histology using an open biopsy showed a proliferation of atypical spindle and asteroid cells with a few foamy lipoblasts in a capillary-rich and myxoid background. The atypical lipoblasts were slightly positive for S-100. These findings were consistent with myxoid liposarcoma. The patient was treated with a resection of the mass. Liposarcoma is considered to be the second most common soft-tissue sarcoma. It usually involves the lower extremities, particularly the thigh, and is very rare in the adult foot. Our case was a rare occurrence of myxoid liposarcoma of the foot diagnosed preoperatively using FNAC.