SOCIAL STRESS INCREASES THE ACQUISITION OF COCAINE SELF-ADMINISTRATION IN MALE AND FEMALE RATS
SOCIAL STRESS INCREASES THE ACQUISITION OF COCAINE SELF-ADMINISTRATION IN MALE AND FEMALE RATS
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DOI：
10.1016/0006-8993(95)00788-r
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发表时间：
1995-11-06
期刊：
影响因子：
2.9
通讯作者：
PIAZZA, PV
中科院分区：
文献类型：
--
作者：
HANEY, M;MACCARI, S;PIAZZA, PV
社会压力对可卡因自我管理的脆弱性的影响进行了研究，在Sprague-Dawley大鼠反复暴露于同性对手的攻击。对两种性别进行了研究，因为尚未确定影响女性自我给药的因素。在一周的时间里，雄性和雌性大鼠在四个不同的场合遇到了一个有攻击性的雄性或哺乳期的雌性对手。对照组雄性和雌性大鼠未暴露于攻击。所有动物均植入颈静脉导管，6天后放入自我给药盒中，在指定的“活动孔”中戳鼻导致注射20 μ l可卡因（0.32 mg/kg）。在一个“不活跃”的洞里戳鼻子没有效果。经历过社会压力的雄性和雌性老鼠比没有失败的对照组自己服用了更多的可卡因。在接触可卡因的最初几天，应激和非应激动物之间在可卡因注射次数上的差异并不存在，但随着时间的推移变得更加明显。社会压力增加了可卡因的反应数量，但没有改变非特异性反应的数量。自我给药的性别差异不显著。因此，社会地位似乎是一个强大的影响，在发病的药物服用行为的雄性和雌性大鼠。
The effect of social stress on the vulnerability to commence cocaine self-administration was examined in Sprague-Dawley rats repeatedly exposed to aggressive attack by a same-sex opponent. Both sexes were studied, since the factors influencing the acquisition of drug self-administration in females have not been defined. Male and female rats encountered an aggressive male or lactating female opponent on four separate occasions over the course of one week. Control male and female rats were not exposed to attack. All animals were implanted with jugular catheters, and six days later placed into the self-administration box, where a nose-poke in the designated 'active hole' resulted in a 20 mu l injection of cocaine (0.32 mg/kg). Nose-pokes in an 'inactive' hole had no effect. Male and female rats that had experienced social stress self-administered more cocaine than non-defeated controls. The difference between the stressed and non-stressed animals in the number of cocaine injections was not present during the first few days of exposure to cocaine, but became more pronounced over time. Social stress increased the number of responses for cocaine, but did not alter the number of non-specific responses. Sex differences in self-administration were not significant. Therefore, social status appears to be a potent influence in the onset of drug taking behavior in both male and female rats.