Serum Apolipoprotein and Lipid Profile Effects of an Oat‐Bran‐Supplemented, Low‐Fat Diet in Children with Elevated Serum Cholesterol
Serum Apolipoprotein and Lipid Profile Effects of an Oat‐Bran‐Supplemented, Low‐Fat Diet in Children with Elevated Serum Cholesterol
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补充燕麦麸的低脂饮食对血清胆固醇升高儿童的血清载脂蛋白和脂质谱的影响
DOI：
10.1111/j.1749-6632.1991.tb43758.x
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发表时间：
1991
影响因子：
5.2
通讯作者：
Stephen Baker
中科院分区：
文献类型：
--
作者：
K. Gold;N. Wong;Alan Tong;S. Bassin;C. Iftner;T. Nguyen;Adnan Khoury;Stephen Baker
胆固醇水平超过185 mg/dL的学龄儿童（平均年龄= 10岁）由注册营养师提供美国心脏协会“第1步”指南，旨在将脂肪摄入量限制在总热量的30%，胆固醇摄入量限制在300 mg/天。然后将儿童随机分为对照组（AHA：n= 24）或燕麦麸皮补充组（燕麦：n= 25），区别在于燕麦组成员包括“即食”燕麦麸皮谷物和小吃棒，随后在为期四周的研究期间每天消耗约38克燕麦麸皮。在研究开始时，研究组在年龄、体重、估计的体脂百分比、血清前白蛋白、血清脂质或载脂蛋白谱方面没有显著差异（见表1）。将研究之前和之后获得的空腹血清样品超冻（-40 ℃），直到可以同时分析前后样品对，以评价血清载脂蛋白A1（apo A1）和B（apo B）以及总（Chol）、低密度（LDL）和高密度脂蛋白胆固醇（HDL）和甘油三酯（Trig）的变化。虽然补充燕麦麸皮的组Chol（-9 mg/dL）、LDL（-8 mg/dL）和HDL（-1 mg/dL）的降低与对照组的降低没有统计学差异，
School-age children (mean age= 10 years) with cholesterol levels over 185 mg/dL were given American Heart Association “step 1” guidelines by registered dietitians intended to limit fat intake to 30% of total calories and cholesterol intake to 300 mg/day. The children were then randomized into control (AHA: n= 24) or oat-bransupplemented (Oat: n= 25) groups, distinguished by the inclusion of “ready-to-eat” oat bran cereals and snack bars given to Oat group members, who subsequently consumed an estimated 38 grams of oat bran per day during the four-week study. Study groups did not differ significantly at study onset in terms of age, weight, estimated percent body fat, serum prealburnin, serum lipid, or apolipoprotein profiles (see TABLE 1). Fasting serum samples obtained before and after the study were superfrozen (-40 C) until pre-post sample pairs could be analyzed concurrently to evaluate for changes in serum apolipoproteins A1 (apo Al) and B (apo B) as well as total (Chol), low-density (LDL), and high-density lipoprotein cholesterol (HDL) and triglycerides (Trig). While oat-bran-supplemented group reductions of Chol (-9 mg/dL), LDL (-8 mg/dL), and HDL (-1 mg/dL) did not differ statistically from control reductions