A MOF-armored zinc-peroxide nanotheranostic platform for eradicating drug resistant bacteria via image-guided and in situ activated photodynamic therapy
A MOF-armored zinc-peroxide nanotheranostic platform for eradicating drug resistant bacteria via image-guided and in situ activated photodynamic therapy
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DOI：
10.1016/j.apmt.2022.101513
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发表时间：
2022-05-20
影响因子：
8.3
通讯作者：
Yang, Shengbing
中科院分区：
文献类型：
--
作者：
Huang, Kai;Li, Fupeng;Yang, Shengbing
纳米抗温药物的开发作为协同检测细菌感染和消除细菌的一种创新策略正引起人们的关注。报道了一种新型的有机近红外探针(ONP)-MOF(ZIF-67)-装甲过氧化锌核壳结构。这些纳米材料是通过图像引导和原位激活的光动力疗法(PDT)根除耐药细菌的“活性氧物种工厂”。ONP可以检测到感染部位上调的ONOO-水平。ONP可以作为显像剂和光敏剂与产生ONOO的MB反应。ZO2@ZIF-67(ZZ)纳米发电机在受感染的弱酸性微环境中同时产生O-2和H2O2。根据探头的照度，可以按需应用PDT来消除细菌。原位激活光动力疗法可以利用少量的纳米材料有效地杀灭耐药细菌，在体外和体内都没有明显的不良反应。ONP@ZO2@ZIF-67(ONP@ZZ)纳米制剂同时消除抗药性细菌，减少炎症，加速伤口愈合。这种新型的纳米抗菌剂可以作为一个有效的抗菌平台，将感染检测和细菌清除协同作用，为临床上日益严峻的耐药细菌挑战带来新的曙光。
The development of nanotheranostic agents is attracting attention as an innovative strategy to synergistically detect bacterial infection and eliminate bacteria. A novel MOF (ZIF-67)-armored zinc peroxide core-shell structure with a loaded organic NIR probe (ONP) is reported herein. These nanomaterials serve as "reactive oxygen species factories " that eradicate drug resistant bacteria with image guided and in situ activated photo dynamic therapy (PDT). The up-regulated levels of ONOO- at infected sites can be detected by the ONP. ONP could react with ONOO- generating MB as an imaging agent and as a photosensitizer. The ZnO2@ZIF-67(ZZ) nanogenerator simultaneously generates O-2 and H2O2 in an infected, weakened acidic microenvironment. The PDT can be applied on-demand to eliminate bacteria depending on illumination of the probe. The in situ activated PDT strategy can effectively exterminate drug-resistant bacteria, using small amounts of nanomaterials, with no obvious adverse effects in vitro and in vivo. The ONP@ZnO2@ZIF-67(ONP@ZZ) nanoagent simultaneously eliminates drug-resistant bacteria, reduces inflammation, and accelerates wound healing. This novel nanotheranostic agent can act as an effective antibacterial platform by integrating infection detection and bacterial eradication synergistically, and bring new light for the increasingly severe challenge of drug-resistant bacteria in clinic.