Direct recording of theta oscillations in primate prefrontal and anterior cingulate cortices
Direct recording of theta oscillations in primate prefrontal and anterior cingulate cortices
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DOI：
10.1152/jn.00730.2005
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发表时间：
2006-05-01
影响因子：
2.5
通讯作者：
Isomura, Y
中科院分区：
文献类型：
--
作者：
Tsujimoto, T;Shimazu, H;Isomura, Y
最近的证据表明，θ频率（4-7 Hz）的人类前扣带皮层（ACC）和额叶皮层的振荡，即额叶中线θ（Fm θ）的振荡，可能涉及在大脑中的注意过程。然而，人们对Fm θ振荡的生理基础知之甚少，因为只有在有限的情况下才允许对人类进行侵入性研究。在本研究中，我们开发了一个猴子模型的Fm θ振荡和定位的发电机的θ波植入在不同的皮层区域的电极。猴子参与了一个自我发起的手部运动任务，等待一段时间。9区（内侧前额叶皮层）和32区（喙侧前扣带回）的θ功率从运动前几秒开始逐渐增加，并在运动后立即达到峰值。当运动得到奖励时，θ波功率达到第二个峰值，而在没有奖励的试验中，θ波功率迅速下降。在9区和32区的θ振荡是相干的，并且相位锁定在一起。这种theta活动可能与“执行注意力”有关，包括自我控制，内部计时和奖励评估。从相似的定位、相应的频率和对注意过程的依赖性来判断，它可能是人类Fm θ振荡的同源物。这种猴子模型对研究额叶皮层的执行功能很有用。
Recent evidence has suggested that theta-frequency (4-7 Hz) oscillations around the human anterior cingulate cortex (ACC) and frontal cortex-that is, frontal midline theta (Fm theta) oscillations-may be involved in attentional processes in the brain. However, little is known about the physiological basis of Fm theta oscillations because invasive study in the human is allowed in only limited cases. In the present study, we developed a monkey model for Fm theta oscillations and located the generators of theta waves using electrodes implanted in various cortical areas. Monkeys were engaged in a self-initiated hand-movement task with a waiting period. The theta power in area 9 (the medial prefrontal cortex) and area 32 (the rostral ACC) was gradually increased from a few seconds before the movement and reached a peak immediately after the movement. When the movement was rewarded, the theta power attained a second peak, whereas it swiftly decreased in the unrewarded trials. Theta oscillations in areas 9 and 32 were coherent and phase locked together. This theta activity may be associated with "executive attention" including self-control, internal timing, and assessment of reward. It is probably a homologue of human Fm theta oscillations, as judged from the similar localization, corresponding frequency, and dependency on attentional processes. The monkey model would be useful for studying executive functions in the frontal cortex.