Usefulness of procalcitonin serum level for the discrimination of severe sepsis from sepsis: A multicenter prospective study
Usefulness of procalcitonin serum level for the discrimination of severe sepsis from sepsis: A multicenter prospective study
复制标题
DOI：
10.1007/s10156-008-0608-1
复制
发表时间：
2008-06-01
影响因子：
2.2
通讯作者：
Satomura, Shinji
中科院分区：
文献类型：
--
作者：
Endo, Shigeatsu;Aikawa, Naoki;Satomura, Shinji
降钙素原血清水平已被推荐为细菌性感染性疾病的新指标。这项前瞻性、多中心研究的目的是确定降钙素原在鉴别脓毒症和严重脓毒症患者中的临床应用价值。共纳入82例患者：20例无全身性炎症反应综合征（SIRS）， 9例有SIRS， 34例有脓毒症，19例有严重脓毒症。严重脓毒症患者降钙素原水平（中位数为36.1 ng/ml）明显高于脓毒症患者（中位数为0.6 ng/ml）。降钙素原临界值为2.0 ng/ml，检测严重脓毒症的敏感性为94.7%，检测脓毒症的特异性为78.1%。血清降钙素原水平与脓毒症相关器官衰竭评估（SOFA）评分之间存在良好的相关性（r = 0.680），但c反应蛋白（CRP）水平与SOFA评分之间没有相关性。综上所述，降钙素原血清水平不仅可用于脓毒症的诊断，而且可用于区分脓毒症和严重脓毒症。
Procalcitonin serum level has been recommended as a new marker of bacterial infectious diseases. The aim of this prospective, multicenter study was to determine the clinical usefulness of procalcitonin in differentiating patients with sepsis from those with severe sepsis. Eighty-two patients were enrolled: 20 without systemic inflammatory response syndrome (SIRS), 9 with SIRS, 34 with sepsis, and 19 with severe sepsis. The patients with severe sepsis had significantly higher procalcitonin levels (median, 36.1 ng/ml) than those with sepsis (median, 0.6 ng/ml). With a procalcitonin cutoff value of 2.0 ng/ml, sensitivity for the detection of severe sepsis and specificity for the detection of sepsis were 94.7% and 78.1 %, respectively. A good correlation was found between the serum procalcitonin level and the Sepsis-Related Organ Failure Assessment (SOFA) score (r = 0.680), although no correlation was found between the C-reactive protein (CRP) level and the SOFA score. In conclusion, the procalcitonin serum level may be useful not only for aiding the diagnosis of sepsis but also for discriminating between sepsis and severe sepsis.