Physics of living systems
Physics of living systems
复制标题
生命系统物理学
DOI：
10.1038/s41567-018-0230-9
复制
发表时间：
2018
期刊：
影响因子：
19.6
通讯作者：
A. Klopper
中科院分区：
文献类型：
--
作者：
A. Klopper
球形奶牛一直是物理学家们试图理解生命系统的一个诱人的比喻。也许有很好的理由：在写下理论时，优雅往往胜过忠诚，当事情变得像生物学中那样混乱时，人们自然倾向于过度简化。但近年来，人们发起了一场运动，试图消除这种耻辱感，并将物理学视为一种工具，用来推测生命系统的意义，而不仅仅是将它们过于简化。本文所展示的数据集旨在展示其中的一些进展，以此作为支持这一方法的一种方式。物理学家和生物学家之间更有意义的合作的部分动力来自于对整个生命科学的定量技术和理论的兴趣激增，部分灵感来自于结构生物学中这种方法的强大历史。越来越多的物理学家和生物学家之间的合作正在引起更多的细胞，发育和行为生物学的预测研究。对这项合作研究的联合资助使这种对话变得更加强大。从将电化学能转化为机械力的分子马达的动力学到蚁群的大规模协调，
The spherical cow has long been a tempting trope to pin on physicists working towards an understanding of living systems. Perhaps with good reason: elegance often trumps fidelity when it comes to writing down theory, and when things get as messy as they do in biology, there’sa natural tendency to oversimplify. But in recent years there has been a campaign to remove this stigma, and to cast physics as a tool for divining meaning in living systems—rather than merely oversimplifying them. The collection presented here aims to showcase some of these advances as a way of championing this approach.Part of the drive toward more meaningful collaboration between physicists and biologists comes from a surge of interest in quantitative techniques and theory across the life sciences, inspired in part by the strong history of such approaches in structural biology. Increasingly, collaborations between physicists and biologists are giving rise to more predictive research in cell, developmental and behavioural biology. And joint funding for this collaborative research is enabling this dialogue to become ever stronger. From the dynamics of molecular motors converting electrochemical energy into mechanical forces to the large-scale coordination of ant colonies, milestones in