Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B
Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B
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DOI：
10.1038/ni1503
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发表时间：
2007-10-01
影响因子：
30.5
通讯作者：
Galli, Stephen J.
中科院分区：
文献类型：
--
作者：
Grimbaldeston, Michele A.;Nakae, Susumu;Galli, Stephen J.
过敏性接触性皮炎，如对毒药、常春藤或毒橡树的反应，以及慢性低剂量紫外线B照射会损害皮肤。肥大细胞产生促炎介质，其被认为加剧这些普遍的获得性免疫或先天性应答。在这里，我们发现，出乎意料的是，肥大细胞基本上限制了与这些反应相关的病理，包括白细胞浸润，表皮增生和表皮坏死。肥大细胞产生的白细胞介素10有助于这些条件下肥大细胞的抗炎或免疫抑制作用。我们的研究结果确定了以前未被认识的功能肥大细胞和肥大细胞衍生的白细胞介素10在限制白细胞浸润，炎症和组织损伤与免疫或先天性反应，可以伤害皮肤。
Allergic contact dermatitis, such as in response to poison, ivy or poison oak, and chronic low-dose ultraviolet B irradiation can damage the skin. Mast cells produce proinflammatory mediators that are thought to exacerbate these prevalent acquired immune or innate responses. Here we found that, unexpectedly, mast cells substantially limited the pathology associated with these responses, including infiltrates of leukocytes, epidermal hyperplasia and epidermal necrosis. Production of interleukin 10 by mast cells contributed to the anti-inflammatory or immunosuppressive effects of mast cells in these conditions. Our findings identify a previously unrecognized function for mast cells and mast cell-derived interleukin 10 in limiting leukocyte infiltration, inflammation and tissue damage associated with immunological or innate responses that can injure the skin.