Hormonal exposures and the risk of intracranial meningioma in women: a population-based case-control study
Hormonal exposures and the risk of intracranial meningioma in women: a population-based case-control study
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DOI：
10.1186/1471-2407-6-152
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发表时间：
2006-06-07
期刊：
影响因子：
3.8
通讯作者：
Van Belle, Gerald
中科院分区：
文献类型：
--
作者：
Custer, Brian;Longstreth, W. T., Jr.;Van Belle, Gerald
背景资料：外源性激素暴露在脑膜瘤的发展中的作用尚不清楚，但这些暴露已被提出作为一个假设来解释这种肿瘤的过度丰富的women.Methods：口服避孕药（OC）或激素替代治疗（HRT）和颅内脑膜瘤的妇女之间的关联进行了调查，使用人口为基础的，匹配的病例对照研究。通过访谈获得了143例病例和286例对照的5年内年龄匹配的暴露。结果：虽然脑膜瘤的风险出现适度升高，在过去的OC用户（OR = 1.5，95%CI 0.8 - 2.7），并在目前的用户（OR = 2.5，95%CI 0.5 - 12.6），置信区间宽。脑膜瘤风险与OC使用时间无显著相关性，同样，脑膜瘤风险与既往使用HRT仅弱相关（OR = 0.7，95%CI 0.4 - 1.3），与当前使用HRT完全无关（OR = 1.0，95%CI 0.5 - 2.2）。在142例可用标本中，2例（1%）表达雌激素受体，而130例（92%）表达孕激素受体（PR）。OC的使用与脑膜瘤PR表达减少而非增加的风险增加相关（OR = 3.2，95%CI 1.3 - 8.0）。总体而言，在绝经后妇女，HRT的使用似乎赋予一个非显着的保护作用，并没有与低或高PR表达meningoma.Conclusion：这项研究发现很少的证据之间的关联脑膜瘤和外源性激素暴露的妇女，但确实表明，一些激素暴露可能会影响肿瘤生物学在这些妇女谁发展脑膜瘤。
Background: The role of exogenous hormone exposures in the development of meningioma is unclear, but these exposures have been proposed as one hypothesis to explain the over-abundance of such tumors in women.Methods: The association between oral contraception (OC) or hormone replacement therapy (HRT) and intracranial meningioma in women was investigated using a population-based, matched case-control study. Exposures for 143 cases and 286 controls matched on age within five years were obtained by interview. Diagnoses were confirmed histopathologically and estrogen and progesterone receptor assays conducted.Results: Although risk of meningioma appeared modestly elevated in past OC users (OR = 1.5, 95% CI 0.8 - 2.7), and in current users (OR = 2.5, 95% CI 0.5 - 12.6), the confidence intervals were wide. No significant association between meningioma risk and duration of OC use was found. Likewise, risk of meningioma was only weakly associated with past use of HRT (OR = 0.7, 95% CI 0.4 - 1.3), and not at all with current use of HRT (OR = 1.0, 95% CI 0.5 - 2.2). Of 142 available specimens, 2 (1%) expressed estrogen receptors, whereas 130 (92%) expressed progesterone receptors (PR). OC use was associated with increased risk of a meningioma expressing less rather than more PR (OR = 3.2, 95% CI 1.3 - 8.0). Overall, in post menopausal women, HRT use appeared to confer a non-significant protective effect, and was not associated with low or high PR expressing meningiomas.Conclusion: This study found little evidence of associations between meningioma and exogenous hormone exposures in women but did suggest that some hormonal exposures may influence tumor biology in those women who develop meningioma.