METHYLPHENIDATE IN CHILDREN WITH SEIZURES AND ATTENTION-DEFICIT DISORDER
METHYLPHENIDATE IN CHILDREN WITH SEIZURES AND ATTENTION-DEFICIT DISORDER
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DOI：
10.1001/archpedi.1989.02150210117030
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发表时间：
1989-09-01
影响因子：
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通讯作者：
TEODORI, J
中科院分区：
文献类型：
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作者：
FELDMAN, H;CRUMRINE, P;TEODORI, J
本研究评估哌甲酯治疗癫痫和注意力缺陷障碍儿童的安全性和有效性。10名儿童，年龄6岁10个月至10岁10个月，没有癫痫发作，同时接受单一的抗癫痫药物，进行了评价，在双盲药物-安慰剂交叉研究与盐酸哌甲酯，每剂量0.3 mg/kg，并给予上午8时和下午12时，上学的日子。哌醋甲酯的使用与Conners教师评定量表和手指敲击任务的统计学显著改善相关，并且与匹配熟悉图形测试和判别反应时间测试的改善趋势相关。在研究期间，没有儿童癫痫发作，随后继续接受精神兴奋剂的儿童也没有癫痫发作。脑电图上癫痫样特征或背景活动没有显著变化，抗癫痫药物水平也没有改变。哌醋甲酯可能是一种安全有效的治疗某些儿童癫痫发作和并发注意力缺陷障碍。
This study assessed the safety and efficacy of methylphenidate in children with seizures and attention-deficit disorder. Ten children, aged 6 years 10 months to 10 years 10 months, without seizures while receiving a single antiepileptic drug, were evaluated in a double-blind medication-placebo crossover study with methylphenidate hydrochloride was administered at 0.3 mg/kg per dose and given at 8 AM and 12 PM on the school days only. The use of methylphenidate was associated with statistically significant improvements on the Conners'' Teacher Rating Scale and on the finger Tapping Task and with trends toward improvement on the Matching Familiar Figures Test and Discriminant Reaction Time tests. No child had seizures during the study period nor subsequently for those who continued receiving psychostimulants. There were no significant changes of epileptiform features or background activity on electroencephalograms and no alterations in antiepileptic drug levels. Methylphenidate may be a safe and effective treatment for certain children with seizures and concurrent attention-deficit disorder.