STUDIES ON KINETICS AND RENAL EXCRETION OF LOW AND HIGH MOLECULAR-WEIGHT DEXTRANS IN PRETERM BABIES, NEWBORNS AND YOUNG INFANTS
STUDIES ON KINETICS AND RENAL EXCRETION OF LOW AND HIGH MOLECULAR-WEIGHT DEXTRANS IN PRETERM BABIES, NEWBORNS AND YOUNG INFANTS
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DOI：
10.1007/bf00480595
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发表时间：
1977-01-01
影响因子：
3.6
通讯作者：
STECHELE, U
中科院分区：
文献类型：
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作者：
EMMRICH, P;BAUMANN, W;STECHELE, U
在休克初始阶段使用低分子量和高分子量葡聚糖已不再有争议。在规划治疗时没有充分考虑新生儿的特殊情况。本研究旨在确定该年龄组中葡聚糖 40 (Rheomacrodex) 和葡聚糖 (Macrodex) 的生物半衰期 [t1/2]。葡聚糖40的t1/2为60分钟，葡聚糖60的t1/2为3小时。早产儿和新生儿在 24 小时内排出的葡聚糖 40 和 60 比婴儿和成人少 25%。成人的正常排泄值只有在生命的第一年末才达到。
Administration of low and high MW dextrans in the initial phase of shock is no longer controversial. The special conditions in newborns were insufficiently considered in planning therapy. This investigation aimed at determining the biological half-lives [t1/2] of dextran 40 (Rheomacrodex) and dextran (Macrodex) in this age group. The t1/2 of dextran 40 was 60 min and that of dextran 60 3 h. Preterm babies and newborns excreted up to 25% less dextran 40 and 60 in 24 h than infants and adults. Normal adult values for excretion were only reached towards the end of the 1st yr of life.