Asymmetric Suzuki-Miyaura cross-coupling of 1-bromo-2-naphthoates using the helically chiral polymer ligand PQXphos
Asymmetric Suzuki-Miyaura cross-coupling of 1-bromo-2-naphthoates using the helically chiral polymer ligand PQXphos
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DOI：
10.1039/c5cc01074h
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发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Suginome, Michinori
中科院分区：
文献类型：
--
作者：
Akai, Yuto;Konnert, Laure;Suginome, Michinori
单手螺旋聚合物配体PQXphos在不对称Suzuki-Miyaura交叉偶联反应中合成了具有高对映选择性的轴向手性联芳酯。使用带有2，4-二甲基-3-戊基酯的溴化萘得到高产率和高对映选择性。任何一种对映体都可以通过使用单一的PQXphos通过溶剂依赖性的螺旋手性开关来选择性地合成。
A single-handed helical polymer ligand PQXphos afforded axially chiral biaryl esters with high enantioselectivities in asymmetric Suzuki-Miyaura cross-coupling. The use of naphthyl bromide bearing a 2,4-dimethyl-3-pentyl ester resulted in both high yields and high enantioselectivities. Either enantiomer could be synthesized selectively by using a single PQXphos through a solvent-dependent switch of the helical chirality.