ROS-cleavable proline oligomer crosslinking of polycaprolactone for pro-angiogenic host response.
ROS-cleavable proline oligomer crosslinking of polycaprolactone for pro-angiogenic host response.
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DOI：
10.1039/c4tb01094a
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发表时间：
2014-11-07
期刊：
影响因子：
--
通讯作者：
Sung HJ
中科院分区：
文献类型：
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作者：
Lee SH;Boire TC;Lee JB;Gupta MK;Zachman AL;Rath R;Sung HJ
采用生物相容性、可水解降解的聚（ε-己内酯）（PCL）与可降解的低聚脯氨酸肽KP7K交联制备了活性氧（ROS）可降解支架。ros介导的可降解性引发了支架良好的宿主反应，包括改善体内细胞浸润和血管生成，表明其在组织工程应用中的独特优势。
A reactive oxygen species (ROS)-degradable scaffold is fabricated by crosslinking biocompatible, hydrolytically-degradable poly(ε-caprolactone) (PCL) with a ROS-degradable oligoproline peptide, KP7K. The ROS-mediated degradability triggers favorable host responses of the scaffold including improved cell infiltration and angiogenesis in vivo, indicating its unique advantages for tissue engineering applications.