The bone mineral density of hip joint was reduced in the initial stage of ankylosing spondylitis?
The bone mineral density of hip joint was reduced in the initial stage of ankylosing spondylitis?
复制标题
强直性脊柱炎初期髋关节骨密度降低？
DOI：
10.1097/md.0000000000019132
复制
发表时间：
2020-02-01
期刊：
影响因子：
1.6
通讯作者：
Zhang, Ping
中科院分区：
文献类型：
--
作者：
Cai, Peng Li;Yan, Yun Yu;Zhang, Ping
摘要骨质疏松症是强直性脊柱炎（AS）的常见并发症，但在发病初期常被忽视。本研究通过对早期AS患者与健康对照组髋关节面骨密度的比较，探讨早期AS患者皮质骨和松质骨丢失的进展。对60例AS患者（改良纽约AS标准，CT显示骶髂关节炎2级）和57例健康对照者进行髋关节定量CT检查。将AS患者的QCT测量值与健康对照组的测量值进行比较。早期AS患者股骨近端皮质骨和全骨的面积BMD低于对照组（P<0.01）。 但AS患者股骨近端松质骨密度与健康对照组无显著性差异。在AS患者和健康对照组中，体重指数BMI、皮质骨的面积BMD（rs = 0.410，P <0.001; rs = 0.422，P <0.001）和总骨的面积BMD（rs = 0.368，P <0.001; rs = 0.266，P = 0.003）之间存在强相关性。 结果表明，AS早期普遍存在骨量减少/骨质疏松。AS早期股骨近端皮质骨质减少/骨质疏松发生早于松质骨。
Abstract The osteoporosis was common complication of ankylosing spondylitis (AS), but it was frequently unrecognized in the initial stage of the disease. This study was to compare areal bone mineral density (BMD) of hip joints in early AS patients with that in healthy controls, to explore the progress of bone loss in cortex and spongiosa in early AS. Quantitative computed tomography (QCT) of hip was performed in 60 AS patients (modified New York criteria for AS, with grade 2 sacroiliitis in computed tomography) and 57 healthy controls. The QCT measurements of AS patients were compared with the measurements of healthy controls. The AS patients had lower areal BMD in cortical bone and total bone of proximal femur in early AS patients (P < .01), than the controls. But there were not significant different of areal BMD in spongiosa of proximal femur between the early AS patients and healthy controls. Strong correlations were found between body mass index BMI, areal BMD in cortical bone (rs = 0.410, P < .001; rs = 0.422, P < .001) and total bone (rs = 0.368, P < .001; rs = 0.266, P = .003) both in AS patients and healthy controls. The results indicate that osteopenia/osteoporosis is general in early stage of AS. What is more, the osteopenia/osteoporosis in cortex is earlier than in spongiosa of proximal femur in early AS.