Pathophysiology of myocardial reperfusion.
Pathophysiology of myocardial reperfusion.
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DOI：
10.1146/annurev.me.36.020185.001013
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发表时间：
1985
影响因子：
10.5
通讯作者：
K. A. Fox;S. R. Bergmann;B. Sobel
中科院分区：
文献类型：
--
作者：
K. A. Fox;S. R. Bergmann;B. Sobel
冠状动脉溶栓诱导心肌再灌注的可行性刺激了急性心肌梗死患者管理的显著变化。尽管在许多患者中取得了明显的成功再通，但有效的组织再灌注并不一定能实现。此外，确定再灌注的风险/益处关系的因素，对受损心肌的有益作用的程度，以及最终赋予患者的长期益处都需要进一步的定义。用于诱导心肌再灌注的干预措施的广泛实施应基于心脏对再灌注的功能和代谢反应的全面表征。这篇选择性的综述考虑了缺血损伤病理生理机制相关的大量信息背景下的再灌注，并讨论了对再灌注的潜在有利和不利反应。
The feasibility of myocardial reperfusion induced by coronary thrombolysis stimulated marked changes in the management of patients with acute myocardial infarction. Despite the demonstrable successful recanalization achieved in many patients, effective tissue reperfusion has not necessarily been achieved. Furthermore, factors defining the risk/benefit relationships of reperfusion, the extent to which salutary effects on jeopardized myocardium can be anticipated, and the ultimate long-term benefit conferred on the patient all require further definition. Widespread implementation of interventions utilized to induce myocardial reperfusion should be based on thorough characterization of the functional and metabolic responses of the heart to reperfusion. This selective review considers reperfusion within the context of an extensive body of information pertinent to the pathophysiological mechanisms underlying ischemic injury and discusses the potential favorable and unfavorable responses to reperfusion.