All-in-one thermometer-heater up-converting platform YF3:Yb3+,Tm3+ operating in the first biological window
All-in-one thermometer-heater up-converting platform YF3:Yb3+,Tm3+ operating in the first biological window
复制标题
一体式温度计-加热器上转换平台 YF3:Yb3 ,Tm3 在第一个生物窗口运行
DOI：
10.1039/c6tc05449h
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发表时间：
2017-02-14
影响因子：
6.4
通讯作者：
Guo, Chongfeng
中科院分区：
文献类型：
--
作者：
Suo, Hao;Hu, Fangfang;Guo, Chongfeng
在一个上转换平台上实现实时诊断和治疗的结合、灵敏的测温和高效的热产生是迈向光热治疗(PTT)的关键一步。在这里，截断的八面体YF_3：Tm~(3+)/Yb~(3+)微晶作为工作在第一生物窗口(BW-I)的温度计的潜力是基于完全分离的3F_2，3/3H_4→_3H_6跃迁的远红-近红外发射的温度响应荧光强度比(FIR)。随着Yb3+含量的增加，与3F2、3/3H4能级相关的交叉驰豫(CR)过程的几率大大增加，导致在生理温度范围内的绝对灵敏度提高了3倍以上。还通过监测样品周围温度随Yb3+剂量、激发时间和980 nm激光二极管密度的变化来评估光热效应。这些结果为优化热敏性和光学加热能力提供了一种有前途的策略，这表明目前的UC平台在PTT中作为实时温度计和光热试剂具有巨大的潜在应用前景。
Achieving the combination of real-time diagnosis and therapy in one up-converting platform with sensitive thermometry and efficient heat production is a critical step towards photo-thermal therapy (PTT). Here, the potentiality of truncated octahedral YF3:Tm3+/Yb3+ micro-crystals as thermometers operating in the first biological window (BW-I) was evaluated on the basis of a thermo-responsive fluorescence intensity ratio (FIR) of far-red to NIR emission from completely separated 3F2,3/3H4 → 3H6 transitions. The probabilities of cross-relaxation (CR) processes related to 3F2,3/3H4 levels were greatly enhanced by increasing the Yb3+ content, leading to an increase of more than three times in the absolute sensitivity within the physiological temperature range. Photo-thermal effects were also assessed by monitoring the variation of temperature around the samples as functions of the Yb3+ dosage, excitation time and density of 980 nm laser diodes. These results offer a promising strategy to optimize the thermal sensitivity and optical heating ability, which indicates that the present UC platform has great potential applications in PTT as real-time thermometers and photo-thermal agents.