Off-resonance saturation as a means of generating contrast with superparamagnetic nanoparticles
Off-resonance saturation as a means of generating contrast with superparamagnetic nanoparticles
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DOI：
10.1002/mrm.21024
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发表时间：
2006-10-01
影响因子：
3.3
通讯作者：
Hu, Xiaoping
中科院分区：
文献类型：
--
作者：
Zurkiya, Omar;Hu, Xiaoping
这项工作展示了一种替代方法，称为非共振饱和（ORS），用于产生对超顺磁性粒子敏感的对比度。该方法导致计算出的对比度随着超顺磁性纳米颗粒浓度而增加。实验数据表明，在超顺磁性粒子的存在下，存在的非共振效应是从磁化转移（MT）的效果不同，是高度依赖于扩散。数据表明，在0.5 × 10（-9）m（2）/s和更慢的速率下，对水扩散的依赖性变得最显著。我们研究了非共振效应对非共振频率和粒子浓度的依赖性。数据表明，在3 T下，500 Hz <垂直条Delta omega垂直条< 1500 Hz的有用频率偏移范围。这种方法可能是特别有用的器官和疾病，其中扩散可能会改变病理。
This work demonstrates an alternative approach, termed off resonance saturation (ORS), for generating contrast that is sensitive to superparamagnetic particles. This method leads to a calculated contrast that increases with superparamagnetic nanoparticle concentration. Experimental data demonstrate that in the presence of superparamagnetic particles, an off-resonance effect exists that is distinct from the magnetization transfer (MT) effect and is highly dependent on diffusion. Data show that the dependence on water diffusion becomes most significant at rates of 0.5 x 10(-9) m(2)/s and slower. We investigated the dependence of the off-resonance effect on off-resonance frequency and particle concentration. The data suggest a useful frequency offset range of 500 Hz < vertical bar Delta omega vertical bar < 1500 Hz at 3T. This approach may be especially useful in organs and diseases in which diffusion may be altered by pathologies.