Correlates of bone quality in older persons
Correlates of bone quality in older persons
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DOI：
10.1016/j.bone.2006.03.014
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发表时间：
2006-10-01
期刊：
影响因子：
4.1
通讯作者：
Ferrucci, L.
中科院分区：
文献类型：
--
作者：
Lauretani, F.;Bandinelli, S.;Ferrucci, L.
研究目的：在一个以人群为基础的样本的老年人，我们研究了胫骨骨密度和几何形状和因素之间的关系可能影响osteoporosis.Methods：在1260名年龄在65岁或以上的参与者有资格的InCHIANTI研究，1155接受了采访，915（79.2%）有完整的数据胫骨QCT扫描和其他变量在这里提出的分析。最终研究人群包括807人（372名男性和435名女性，年龄范围65-96岁），排除了受骨疾病影响或用干扰骨代谢的药物治疗的参与者。无论男女，小腿肌肉横截面积（CSMA）与总骨横截面积（tCSA）和皮质骨横截面积（cCSA），但不与骨小梁或皮质体积骨矿物质密度（vBMD）相关。在两种性别中，生物可利用睾酮（Bio-T）与骨小梁和皮质vBMD独立相关。在女性中，独立于混杂因素，25（OH）-维生素D与tCSA和皮质vBMD呈正相关，而PTH与皮质vBMD呈负相关。IL-1 β与女性皮质vBMD呈负相关，而TNF-α与增强的骨几何adaptationin men.Conclusions：一般认为是骨质疏松症的危险因素的生理参数与胫骨QCT评估的特定骨参数相关。已知与骨重吸收增加相关的因素，如25（OH）-维生素D、PTH和Bio-T，主要影响体积BMD，而与骨机械刺激相关的因素，如CSMA，主要影响骨几何形状。我们的研究结果还表明，促炎细胞因子可能被认为是骨吸收的标志物。(c)2006年爱思唯尔公司All rights reserved.
Purpose of the study: In a population-based sample of older persons, we studied the relationship between tibial bone density and geometry and factors potentially affecting osteoporosis.Methods: Of the 1260 participants aged 65 years or older eligible for the InCHIANTI study, 1155 received an interview and 915 (79.2%) had complete data on tibial QCT scans and other variables used in the analysis presented here. The final study population included 807 persons (3 72 men and 43 5 women, age range 65-96 years) after exclusion of participants affected by bone diseases or treated with drugs that interfere with bone metabolism.Results: In both sexes, calf cross-sectional muscle area (CSMA) was significantly and independently associated with total bone cross-sectional area (tCSA) and cortical bone cross-sectional area (cCSA) but not with trabecular or cortical volumetric bone mineral density (vBMD). Bioavailable testosterone (Bio-T) was independently associated with both trabecular and cortical vBMD in both sexes. In women, independently of confounders, 25(OH)-vitamin D was positively associated with tCSA and cortical vBMD, while PTH was negatively associated with cortical vBMD. IL-1 beta was negatively correlated with cortical vBMD in women, while TNF-alpha was associated with enhanced bone geometrical adaptation in men.Conclusions: Physiological parameters that are generically considered risk factors for osteoporosis were associated with specific bone parameters assessed by tibial QCT. Factors known to be associated with increased bone reabsorption, such as 25(OH)-vitamin D, PTH and Bio-T, affected mainly volumetric BMD, while factors associated with bone mechanical stimulation, such as CSMA, affected primarily bone geometry. Our results also suggested that pro-inflammatory cytokines might be considered as markers of bone resorption. (c) 2006 Elsevier Inc. All rights reserved.