Reduced nicotine content cigarettes: effects on toxicant exposure, dependence and cessation
Reduced nicotine content cigarettes: effects on toxicant exposure, dependence and cessation
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DOI：
10.1111/j.1360-0443.2009.02780.x
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发表时间：
2010-02-01
期刊：
影响因子：
6
通讯作者：
Hecht, Stephen S.
中科院分区：
文献类型：
--
作者：
Hatsukami, Dorothy K.;Kotlyar, Michael;Hecht, Stephen S.
目的探讨尼古丁含量降低的香烟对吸烟行为、毒物暴露、依赖和戒烟的影响。设计随机、平行、半盲研究。地点：明尼苏达大学烟草使用研究中心。干预：6周：（i）0.05 mg尼古丁含量香烟;（ii）0.3 mg尼古丁含量香烟;（iii）4 mg尼古丁含片;随访6周，测量补偿性吸烟行为、暴露生物标志物、烟草依赖、烟草戒断和戒烟率。此外，0.05 mg香烟和尼古丁含片与降低致癌物暴露、尼古丁依赖和产品戒断评分相关。与尼古丁含片相比，0.05 mg香烟与从普通品牌香烟戒断的更大缓解相关。0.05毫克的香烟导致了一个显着较高的戒烟率比0.3毫克的香烟和类似的尼古丁lozene.ConclusionThe 0.05毫克尼古丁产量香烟可能是一种烟草产品，可以促进戒烟，但是，未来的研究显然是需要支持这些初步的研究结果。
AimsTo examine the effects of reduced nicotine cigarettes on smoking behavior, toxicant exposure, dependence and abstinence.DesignRandomized, parallel arm, semi-blinded study.SettingUniversity of Minnesota Tobacco Use Research Center.InterventionsSix weeks of: (i) 0.05 mg nicotine yield cigarettes; (ii) 0.3 mg nicotine yield cigarettes; or (iii) 4 mg nicotine lozenge; 6 weeks of follow-up.MeasurementsCompensatory smoking behavior, biomarkers of exposure, tobacco dependence, tobacco withdrawal and abstinence rate.FindingsUnlike the 0.3 mg cigarettes, 0.05 mg cigarettes were not associated with compensatory smoking behaviors. Furthermore, the 0.05 mg cigarettes and nicotine lozenge were associated with reduced carcinogen exposure, nicotine dependence and product withdrawal scores. The 0.05 mg cigarette was associated with greater relief of withdrawal from usual brand cigarettes than the nicotine lozenge. The 0.05 mg cigarette led to a significantly higher rate of cessation than the 0.3 mg cigarette and a similar rate as nicotine lozenge.ConclusionThe 0.05 mg nicotine yield cigarettes may be a tobacco product that can facilitate cessation; however, future research is clearly needed to support these preliminary findings.