Clinicopathological Findings of Four Cases of Pure Influenza Virus A Pneumonia
Clinicopathological Findings of Four Cases of Pure Influenza Virus A Pneumonia
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DOI：
10.2169/internalmedicine.53.1174
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发表时间：
2014-01-01
影响因子：
1.2
通讯作者：
Tateyama, Masao
中科院分区：
文献类型：
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作者：
Fujita, Jiro;Ohtsuki, Yuji;Tateyama, Masao
目的探讨单纯甲型流感病毒性肺炎的临床病理特点，方法对4例单纯甲型流感病毒性肺炎患者进行临床病理分析，其中3例为2009年甲型H1N1流感病毒所致。三例进行了分析，在尸检过程中，一个进行了transbronchial肺biopsiz.Results我们建议，流感病毒A肺炎发作和我们的分析之间的时间间隔影响的病理结果。在急性期观察到弥漫性肺泡损伤。10天后，观察到机化性肺炎和早产II型肺泡上皮细胞的显著增殖。临床上，在两名患者中观察到肺泡内出血。结论严重的肺泡上皮细胞损伤是甲型流感病毒肺炎致呼吸衰竭的主要机制。
Objective The purpose of this study was to perform clinicopathological evaluations of patients with pure influenza A virus pneumonia.Methods We performed clinicopathological analyses of four cases of pure influenza A virus pneumonia.Patients Among the four cases, three were caused by the pandemic (H1N1) 2009 virus. Three patients were analyzed during autopsy, and one underwent transbronchial lung biopsy.Results We suggest that the interval between influenza virus A pneumonia onset and our analysis affected the pathological findings. Diffuse alveolar damage was observed during the acute phase. After ten days, organizing pneumonia and marked proliferation of premature type II alveolar epithelium were observed. Clinically, intra-alveolar hemorrhage was observed in two patients. Pathologically, hyaline membrane formation and intra-alveolar hemorrhage were observed in all cases.Conclusion Severe epithelial damage was determined as the main mechanism of respiratory failure caused by influenza A virus pneumonia.