Adipocytokines and hepatic fibrosis.
Adipocytokines and hepatic fibrosis.
复制标题
DOI：
10.1016/j.tem.2015.01.002
复制
发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Anania FA
中科院分区：
文献类型：
--
作者：
Saxena NK;Anania FA
Obesity and metabolic syndrome pose significant risk for progression of many types of chronic illnesses, including liver disease. Hormones released from adipocytes, adipocytokines, associated with obesity and metabolic syndrome, have been shown to control hepatic inflammation and fibrosis. Hepatic fibrosis is the final common pathway that can result in cirrhosis, and can ultimately require liver transplantation. Initially, two key adipocytokines, leptin and adiponectin, appeared to control many fundamental aspects of the cell and molecular biology related to hepatic fibrosis and its resolution. Leptin appears to act as a profibrogenic molecule while adiponectin possesses strong-anti-fibrotic properties. In this review, we emphasize pertinent data associated with these, and recently discovered, adipocytokines that may drive or halt the fibrogenic response in the liver.
