A rare cause of acute flaccid paralysis: Human coronaviruses
A rare cause of acute flaccid paralysis: Human coronaviruses
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DOI：
10.4103/1817-1745.165716
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发表时间：
2015-07-01
影响因子：
0.5
通讯作者：
Haydar, A. Tasdemir
中科院分区：
文献类型：
--
作者：
Turgay, Cokyaman;Emine, Tekin;Haydar, A. Tasdemir
急性弛缓性麻痹（AFP）是一种危及生命的临床疾病，其特征是全身肌肉无力，常伴有呼吸和球麻痹。最常见的病因是Gullian-Barre综合征，但感染、脊髓疾病、神经肌肉疾病（如重症肌无力）、药物和毒素、周期性低钾性麻痹、电解质紊乱和肉毒中毒也应作为鉴别诊断的考虑因素。人类冠状病毒（HCoVs）引起普通感冒、上呼吸道和下呼吸道疾病，但文献中未见与下呼吸道感染和AFP相关的报道。本研究首次报道了采用实时聚合酶链反应检测HCoV 229E和OC43合并感染的小儿下呼吸道感染和AFP住院病例。
Acute flaccid paralysis (AFP) is a life-threatening clinical entity characterized by weakness in the whole body muscles often accompanied by respiratory and bulbar paralysis. The most common cause is Gullian-Barre syndrome, but infections, spinal cord diseases, neuromuscular diseases such as myasthenia gravis, drugs and toxins, periodic hypokalemic paralysis, electrolyte disturbances, and botulism should be considered as in the differential diagnosis. Human coronaviruses (HCoVs) cause common cold, upper and lower respiratory tract disease, but in the literature presentation with the lower respiratory tract infection and AFP has not been reported previously. In this study, pediatric case admitted with lower respiratory tract infection and AFP, who detected for HCoV 229E and OC43 co-infection by the real-time polymerase chain reaction, has been reported for the first time.