Cytotoxic constituents of the fruits of Cananga odorata
Cytotoxic constituents of the fruits of Cananga odorata
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DOI：
10.1021/np0005208
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发表时间：
2001-05-01
影响因子：
5.1
通讯作者：
Wu, YC
中科院分区：
文献类型：
--
作者：
Hsieh, TJ;Chang, FR;Wu, YC
从香藤（Cananga odorata）果实中分得一个新的愈创木啶倍半萜生物碱cananodine（1）和两个新的桉烷倍半萜类化合物cryptomeridiol 11-alpha -L-鼠李糖苷（2）和γ-桉烷醇11-alpha -L-鼠李糖苷（3），以及沿着的γ-桉烷醇（4）。化合物1-3的结构经NMR和MS确证。此外，评价了化合物1-4和四种先前报道的生物碱，即隐孢子虫碱（5）、N-反式-阿魏酰酪胺（8）、（+）-ushinsunine-β-N-氧化物（7）和来斯卡明（8）对两种人肝癌细胞系的细胞毒性。
A new guaipyridine sesquiterpene alkaloid, cananodine (1), and two new eudesmane sesquiterpines, cryptomeridiol 11-alpha -L-rhamnoside (2) and gamma -eudesmol 11-alpha -L-rhamnoside (3), along with gamma -eudesmol (4), were isolated from the fruits of Cananga odorata. The structures of compounds 1-3 were established on the basis of NMR and MS methods. In addition, compounds 1-4 and four previously reported alkaloids, cleistopholine (5), N-trans-feruloyltyramine (8), (+)-ushinsunine-beta -N-oxide (7), and lyscamine (8), were evaluated for cytotoxicity against two human hepatocarcinoma cell lines.