Is abundant A-to-I RNA editing primate-specific?
Is abundant A-to-I RNA editing primate-specific?
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DOI：
10.1016/j.tig.2004.12.005
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发表时间：
2005-02-01
影响因子：
11.4
通讯作者：
Levanon, EY
中科院分区：
文献类型：
--
作者：
Eisenberg, E;Nemzer, S;Levanon, EY
A-to-I RNA编辑在所有真核生物中很常见，并且与各种神经功能相关。最近，A-to-I编辑被发现在人类转录组中频繁发生。在这篇文章中，我们表明人类中A到I编辑的频率至少比小鼠，大鼠，鸡或苍蝇基因组高一个数量级。人类中RNA编辑的异常频率可以通过人类转录组中特定的Alu元件的优势来解释，这增加了双链RNA底物的数量。
A-to-I RNA editing is common in all eukaryotes, and is associated with various neurological functions. Recently, A-to-I editing was found to occur frequently in the human transcriptome. In this article, we show that the frequency of A-to-I editing in humans is at least an order of magnitude higher than in the mouse, rat, chicken or fly genomes. The extraordinary frequency of RNA editing in human is explained by the dominance of the prim ate-specific Alu element in the human transcriptome, which increases the number of double-stranded RNA substrates.