AVERSIVE ATTRIBUTES OF ETHANOL CAN BE ATTENUATED BY DYADIC SOCIAL-INTERACTION IN THE RAT
AVERSIVE ATTRIBUTES OF ETHANOL CAN BE ATTENUATED BY DYADIC SOCIAL-INTERACTION IN THE RAT
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DOI：
10.1016/0741-8329(94)90038-8
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发表时间：
1994-05-01
期刊：
影响因子：
2.3
通讯作者：
HOLLOWAY, FA
中科院分区：
文献类型：
--
作者：
GAUVIN, DV;BRISCOE, RJ;HOLLOWAY, FA
48只雄性Sprague-Dawley大鼠接受水或4 g/kg乙醇的训练，进行标准的药物位置学习任务。除了药物治疗外，各组与清醒或醉酒的同种动物进行社交互动的机会也各不相同（N = 8只/组）。乙醇产生了强烈的条件厌恶。与清醒或醉酒的群体进行二元社会互动的机会减弱了乙醇的厌恶属性。然而，在隔离的水条件大鼠中，或者在清醒或醉酒的队列中，初始偏好得分没有显着变化。这些数据与临床报告相似，表明社会因素可以影响乙醇的厌恶情感特性。
Forty-eight male Sprague-Dawley rats were conditioned with either water or 4 g/kg ethanol in a standard drug place-learning task. In addition to the drug treatment, the opportunity for social interaction with either a sober or intoxicated conspecific was varied across groups (N = 8 rats/group). Ethanol produced a robust conditioned place aversion. The opportunity for dyadic social interaction with either a sober or intoxicated cohort attenuated the aversive attributes of ethanol. However, the initial preference scores did not significantly shift in water-conditioned rats in isolation or given access to either a sober or intoxicated cohort. These data are similar to clinical reports and suggest that social factors can influence the aversive affective properties of ethanol.