Enantioselective Mannich‐type Reactions to Construct CF3S‐containing Stereocenters Catalyzed by Chiral Quaternary Phosphonium Salts
Enantioselective Mannich‐type Reactions to Construct CF3S‐containing Stereocenters Catalyzed by Chiral Quaternary Phosphonium Salts
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手性季鏻盐催化对映选择性曼尼希型反应构建含CF3S的立构中心
DOI：
10.1002/adsc.201901621
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发表时间：
2020
影响因子：
5.4
通讯作者：
Gang Zhao
中科院分区：
文献类型：
--
作者：
Lijun Xu;Longhui YU;Jun Liu;Hongyu Wang;Changwu Zheng;Gang Zhao
利用一系列带有硝基的苄基三氟甲基硫醚作为含CF 3S的结构单元，通过对映选择性乙烯基Mannich-型反应构建手性含CF 3S的分子。在这样的反应中，使用衍生自氨基酸的手性季鏻盐获得高产率和对映选择性。此外，通过进一步转化产物，获得了带有CF 3S部分的手性环脲。
A series of benzyl trifluoromethyl sulphides bearing a nitro group were utilized as CF3S‐containing building blocks to construct chiral CF3S‐containing molecules via enantioselective vinylogous Mannich‐type reactions. In such reactions, high yields and enantioselectivities were obtained using chiral quaternary phosphonium salts derived from amino acids. Moreover, a chiral cyclic urea bearing the CF3S moiety was obtained from further transformation of the product.