Chronic diseases requiring hospitalization and risk of non-melanoma skin cancers - A population based study from Denmark
Chronic diseases requiring hospitalization and risk of non-melanoma skin cancers - A population based study from Denmark
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DOI：
10.1038/sj.jid.5701094
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发表时间：
2008-04-01
影响因子：
6.5
通讯作者：
Karagas, Margaret R.
中科院分区：
文献类型：
--
作者：
Jensen, Annette O.;Olesen, Anne B.;Karagas, Margaret R.
我们通过一项以人群为基础的病例对照研究，研究了需要住院治疗的慢性病与非黑色素瘤皮肤癌 (NMSC) 风险之间的关联，该研究纳入了 1995 年在丹麦诊断出首例原发性 NMSC 的 4,187 名患者。我们从涵盖丹麦所有医院的国家患者登记处获得了 NMSC 诊断日期之前记录的慢性病住院数据。通过发病密度抽样，我们从丹麦民事登记系统中选择了 10 个年龄、性别和居住地匹配的对照。我们使用条件逻辑回归来计算发生率比 (IRR) 和 95% 置信区间 (CI)。尽管未发现基底细胞癌 (BCC) 与慢性病住院之间存在总体关联，但结缔组织病 (IRR 1.34 (95% CI: 0.99-1.82))、移植 (IRR 8.00 (95% CI: 2.15-30)) 和淋巴瘤 (IRR 2.50 (95% CI: 2.15-30)) 患者中 BCC 的 IRR 较高1.29-4.84））。鳞状细胞癌 (SCC) 与慢性疾病住院之间存在总体关联，并且在白血病 (IRR 7.75 (95% CI: 2.35-26))、淋巴瘤 (IRR 3.86 (95% CI: 0.99-15)) 和皮肤病 (IRR 5.28 (95% CI: 1.95-14)) 患者中具有特异性。我们的研究支持某些慢性疾病与 NMSC 之间存在关联，并进一步表明这些结果不太可能是由于偏差造成的。
We examined the associations between chronic diseases requiring hospitalization and the risk of non-melanoma skin cancers (NMSCs) in a population-based case-control study of 4,187 patients diagnosed with a first primary NMSC in 1995 in Denmark. From the National Patient Registry covering all Danish hospitals, we obtained data on hospitalizations with chronic diseases, recorded before the date of NMSC diagnosis. Using incidence density sampling, we selected 10 age-, gender-, and residence-matched controls from the Danish Civil Registration System. We used conditional logistic regression to compute incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Although no overall association was found between basal cell carcinoma (BCC) and hospitalization for chronic diseases, an elevated IRR for BCC was found among patients with connective tissue disease (IRR 1.34 (95% CI: 0.99-1.82)), transplants (IRR 8.00 (95% CI: 2.15-30)), and lymphoma (IRR 2.50 (95% CI: 1.29-4.84)). An overall association between squamous cell carcinoma (SCC) and hospitalization for chronic diseases was found and specific among patients with leukemia (IRR 7.75 (95% CI: 2.35-26)), lymphoma (IRR 3.86 (95% CI: 0.99-15)), and skin diseases (IRR 5.28 (95% CI: 1.95-14)). Our study supports the presence of an association between certain chronic diseases and NMSC, and further suggests that these results unlikely are due to bias.