Psychological distress and natural killer cells in gay men with and without HIV infection.
Psychological distress and natural killer cells in gay men with and without HIV infection.
复制标题
感染和未感染艾滋病毒的男同性恋者的心理困扰和自然杀伤细胞。
DOI：
10.1176/ajp.151.10.1479
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Gorman,JM
中科院分区：
文献类型：
--
作者：
Sahs,JA;Goetz,R;Reddy,M;Rabkin,JG;Williams,JB;Kertzner,R;Gorman,JM
目的HIV感染者免疫功能下降的差异性增加了心理因素可能有助于解释这种差异的可能性。由于对其他人群的研究表明自然杀伤(NK)细胞会受到精神疾病的影响，作者在HIV感染的背景下对这种关系进行了研究，期望发现较少的NK细胞与更大的心理痛苦有关。方法参与一项纵向研究的46名HIV阴性和74名HIV阳性的男同性恋者在进入研究36个月后进行了NK细胞计数(CD56染色)。对HIV阴性、HIV阳性、无症状和HIV阳性的有症状男性进行心理功能和自然杀伤细胞绝对数的临床评定和自我报告，并进行比较。这两组人对心理痛苦的测量在任何临床意义上都没有不同。结论HIV感染者和非HIV感染者的NK细胞数与心理困扰程度无关。
ObjectiveThe variability of the decline in immune function among those infected by HIV raises the possibility that psychological factors might help to explain the differences. Since studies of other populations have shown natural killer (NK) cells to be affected by psychiatric conditions, the authors examined this relationship in the context of HIV infection, expecting to find fewer NK cells to be associated with greater psychological distress.MethodForty-six HIV-negative and 74 HIV-positive gay men who were participating in a longitudinal study had NK cells enumerations performed (by staining for CD56) 36 months after entry into the study. Comparisons were made between HIV-negative, HIV-positive asymptomatic, and HIV-positive symptomatic men by using a variety of clinician-rated and self-report measures of psychological function and absolute NK cell number.ResultsHIV-negative men had more NK cells than the groups of HIV-positive men. The groups' measures of psychological distress did not differ in any clinically meaningful ways. In general, the presence of DSM-III-R diagnoses and the measures of distress did not relate to NK cell number.ConclusionsNK cell number is not related to measures of psychological distress in these gay men with and without HIV infection.