Prevalence and Baseline Clinical Characteristics of Eosinophilic Chronic Obstructive Pulmonary Disease: A Meta-Analysis and Systematic Review
Prevalence and Baseline Clinical Characteristics of Eosinophilic Chronic Obstructive Pulmonary Disease: A Meta-Analysis and Systematic Review
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嗜酸性粒细胞性慢性阻塞性肺疾病的患病率和基线临床特征：荟萃分析和系统评价
DOI：
10.3389/fmed.2019.00282
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发表时间：
2019
影响因子：
3.9
通讯作者：
D. Cheng
中科院分区：
文献类型：
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作者：
Hongxia Wu;K. Zhuo;D. Cheng
背景：慢性阻塞性肺疾病（COPD）是一种异质性疾病，具有不同的临床和病理生理特征。累积证据表明，嗜酸性粒细胞水平可能与慢性阻塞性肺病的治疗效果和表型有关。然而，COPD中嗜酸性粒细胞炎症的患病率和嗜酸性粒细胞性COPD的基线特征仍然未知。我们的研究调查了嗜酸性粒细胞水平为bb0.2 %的COPD患病率以及嗜酸性COPD的特征。方法：我们检索了Cochrane中央图书馆、Medline、Embase和Web of Science，检索了从数据库建立到2019年5月1日发表的嗜酸性粒细胞和COPD的试验。结果：总共有40112名COPD患者参与了19项试验，被纳入最终分析。嗜酸性粒细胞性COPD的患病率从18.84%到66.88%不等，所有研究的平均患病率为54.95%。我们发现，男性、戒烟者、有缺血性心脏病史的个体和身体质量指数（BMI）较高的个体患嗜酸性慢性阻塞性肺病的风险较高（OR 1.36, 95% CI 1.26-1.46, P < 0.00001; OR 1.23, 1.12-1.34, P < 0.0001; OR 1.31, 1.14-1.50, P = 0.001; MD 0.70, 0.27-1.12, P = 0.001）。然而，嗜酸性COPD患者中GOLD期患者比例较低（OR = 0.84, 0.73-0.96, P = 0.01）。两组在年龄、吸烟现状、吸烟包年数、预计15秒用力呼气量百分比、高血压、糖尿病或其他GOLD分期方面均无显著差异（P < 0.05）。结论：我们的分析表明，嗜酸性粒细胞炎症在COPD中普遍存在。嗜酸性慢性阻塞性肺病更容易发生在男性、戒烟者、BMI较高者和有某些合并症高风险者；然而，较低比例的嗜酸性COPD患者出现轻度气流受限。
Background: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with different clinical and pathophysiological characteristics. Cumulative evidence shows that eosinophil levels may be connected to the therapeutic effects and phenotype of COPD. However, the prevalence of eosinophilic inflammation in COPD and the baseline characteristics of eosinophilic COPD remain unknown. Our study investigated the prevalence of COPD with eosinophil levels of >2% and the characteristics of eosinophilic COPD. Methods: We searched the Cochrane Central Library, Medline, Embase, and the Web of Science for trials of eosinophil and COPD published from database inception to May 1, 2019. Results: In total, 40,112 COPD patients that were involved in 19 trials were included in the final analysis. The prevalence of eosinophilic COPD ranged from 18.84 to 66.88%, with an average prevalence of 54.95% across all studies. We found that men, ex-smokers, individuals with a history of ischemic heart disease, and individuals with a higher body mass index (BMI) were at higher risk of eosinophilic COPD (OR 1.36, 95% CI 1.26–1.46, P < 0.00001; OR 1.23, 1.12–1.34, P < 0.0001; OR 1.31, 1.14–1.50, P = 0.001; MD 0.70, 0.27–1.12, P = 0.001). There was, however, a lower proportion of GOLD stage I patients among those with eosinophilic COPD (OR 0.84, 0.73–0.96, P = 0.01). No significant differences were found in terms of age, current smoker status, pack-years smoked, percent of predicted forced expiratory volume in 1 s, hypertension, diabetes, or other GOLD stages between the two groups (P > 0.05). Conclusions: Our analysis suggests that eosinophilic inflammation is prevalent in COPD. Eosinophilic COPD was more likely to occur in men, ex-smokers, those with a higher BMI, and those with a high risk of some comorbidity; however, a lower proportion of patients with eosinophilic COPD experienced mild airflow limitations.
DOI：
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发表时间：
2018
期刊：
--
影响因子：
--
作者：
Prof AT Hastie;Prof FJ Martinez;Prof JL Curtis;Prof CM Doerschuk;N. Hansel;S. Christenson;N. Putcha;V. Ortega;X. Li;Prof RG Barr;E. Carretta;Prof DJ Couper;Prof CB Cooper;E. Hoffman;Prof RE Kanner;E. Kleerup;W. O’Neal;R. Prof;Paine;Prof SP Peters;Prof NE Alexis;P. Woodruff;Mk;Han;Prof DA Meyers;Prof ER Bleecker
通讯作者：
Prof AT Hastie;Prof FJ Martinez;Prof JL Curtis;Prof CM Doerschuk;N. Hansel;S. Christenson;N. Putcha;V. Ortega;X. Li;Prof RG Barr;E. Carretta;Prof DJ Couper;Prof CB Cooper;E. Hoffman;Prof RE Kanner;E. Kleerup;W. O’Neal;R. Prof;Paine;Prof SP Peters;Prof NE Alexis;P. Woodruff;Mk;Han;Prof DA Meyers;Prof ER Bleecker
DOI：
10.1164/rccm.200903-0324oc
发表时间：
2009-12-15
影响因子：
24.7
作者：
Malhotra, Deepti;Thimmulappa, Rajesh;Biswal, Shyam
通讯作者：
Biswal, Shyam