U12 intron positions are more strongly conserved between animals and plants than U2 intron positions.
U12 intron positions are more strongly conserved between animals and plants than U2 intron positions.
复制标题
与U2内含子位置相比，在动物和植物之间，U12内含子位置更为强烈。
DOI：
10.1186/1745-6150-3-19
复制
发表时间：
2008-05-14
期刊：
影响因子：
5.5
通讯作者：
Koonin, Eugene V.
中科院分区：
文献类型：
--
作者：
Basu, Malay Kumar;Makalowski, Wojciech;Rogozin, Igor B.;Koonin, Eugene V.
我们报告说，在人类和拟南芥的同源基因中，次要的U12内含子的位置比主要的U2内含子的位置保守得更多。U12内含子，特别是保守的内含子，集中在动植物基因的5‘端，而U12向U2的转换优先发生在基因的3’端。这些结果与以下假设是一致的，即尽管U12向U2的单向转换，但U12内含子位置的高度保守及其在基因组中的持久性是通过缓慢切除的U12内含子在基因表达下调中的作用来解释的。本文由约翰·洛格斯顿和龙曼元撰写。要获得完整的评论，请转到评论者报告部分。
We report that the positions of minor, U12 introns are conserved in orthologous genes from human and Arabidopsis to an even greater extent than the positions of the major, U2 introns. The U12 introns, especially, conserved ones are concentrated in 5'-portions of plant and animal genes, where the U12 to U2 conversions occurs preferentially in the 3'-portions of genes. These results are compatible with the hypothesis that the high level of conservation of U12 intron positions and their persistence in genomes despite the unidirectional U12 to U2 conversion are explained by the role of the slowly excised U12 introns in down-regulation of gene expression. This article was reviewed by John Logsdon and Manyuan Long. For the full reviews, please go to the Reviewers' Reports section.
登录
查看更多内容
影响因子：
64.8
作者：
Russell, Anthony G.;Charette, J. Michael;Gray, Michael W.
通讯作者：
Gray, Michael W.
影响因子：
14.9
作者：
Zhu, W;Brendel, V
通讯作者：
Brendel, V
影响因子：
3.4
作者：
Carmel, Liran;Rogozin, Igor B.;Koonin, Eugene V.
通讯作者：
Koonin, Eugene V.
影响因子：
3.5
作者：
Sverdlov, AV;Babenko, VN;Koonin, EV
通讯作者：
Koonin, EV
影响因子：
16
作者：
Burge, CB;Padgett, RA;Sharp, PA
通讯作者：
Sharp, PA