Nickel Catalyzed Intermolecular Carbonyl Addition of Aryl Halide
Nickel Catalyzed Intermolecular Carbonyl Addition of Aryl Halide
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DOI：
10.1002/ejoc.201901367
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发表时间：
2019-11
影响因子：
2.8
通讯作者：
Seima Ishida;Hiroyuki Suzuki;S. Uchida;E. Yamaguchi;A. Itoh
中科院分区：
文献类型：
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作者：
Seima Ishida;Hiroyuki Suzuki;S. Uchida;E. Yamaguchi;A. Itoh
在这项研究中，我们开发了一种镍催化的羰基芳基化反应，该反应使用醛与芳基和烯丙基卤化物。各种芳基、α,β-不饱和醛和脂肪醛可以中等到高产率转化为相应的仲醇。此外，我们扩展了这种方法，开发了一种不对称还原偶联反应，将镍盐与手性双恶唑啉配体结合，得到具有中等对映选择性的仲醇。
In this study, we develop a nickel‐catalyzed carbonyl arylation reaction employing aldehydes with aryl and allyl halides. Various aryl, α,β‐unsaturated aldehyde and aliphatic aldehydes can be converted into their corresponding secondary alcohols in moderate‐to‐high yields. In addition, we extended this approach to develop an asymmetric reductive coupling reaction that combines nickel salts with chiral bisoxazoline ligands to give secondary alcohols with moderate enantioselectivity.