CD70 expression patterns in renal cell carcinoma.
CD70 expression patterns in renal cell carcinoma.
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DOI：
10.1016/j.humpath.2011.10.014
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发表时间：
2012-09
期刊：
影响因子：
3.3
通讯作者：
Camp, Robert L.
中科院分区：
文献类型：
--
作者：
Jilaveanu, Lucia B.;Sznol, Joshua;Aziz, Saadia A.;Duchen, Dylan;Kluger, Harriet M.;Camp, Robert L.
CD70在几种恶性肿瘤中上调，在那里它诱导B和T淋巴细胞的细胞毒性作用，导致免疫逃逸。靶向CD70的新型治疗药物已进入临床试验阶段。我们对不同组织学亚型的RCC标本中CD70蛋白的表达进行了表征，并评估了其预后价值及其与临床/病理变量的关系。我们采用了包含330例病例的组织微阵列，采用了一种新的基于荧光免疫组织化学的原位蛋白表达自动定量分析（AQUA）方法。肿瘤组织中CD70的平均表达量几乎是正常组织的两倍（p<0.0001）。当划分亚群时，CD70在肉瘤样细胞瘤和透明细胞瘤中较高（p<0.0001），而在癌细胞瘤和一些乳头状瘤中不同程度地升高。CD70表达与分期或分级无相关性。在RCC透明细胞亚群的单因素分析中，高CD70表达与生存率降低相关，但在多变量分析中，它不具有显著性。鉴于CD70在透明细胞、肉瘤样肿瘤和一些乳头状肿瘤中的表达升高，我们的研究结果表明CD70可能是RCC的一个很好的药物靶点。需要进一步的研究来评估RCC中CD70表达与CD70靶向药物治疗反应之间的关系。
CD70 is upregulated in several malignancies, where it induces cytotoxic effects on B and T lymphocytes leading to immune escape. Novel therapeutic agents targeting CD70 have entered clinical trials. We characterized expression of CD70 protein in RCC specimens of various histologic subtypes and assessed their prognostic value and association with clinical/pathological variables. We employed tissue microarrays containing 330 cases using a novel fluorescent immunohistochemistry-based method of Automated Quantitative Analysis (AQUA) of in situ protein expression. The mean expression of CD70 was almost twice as high in tumors relative to normal tissue (p<0.0001). When broken into subsets, CD70 was higher in sarcomatoid and clear cell tumors (p<0.0001), and variably elevated in oncocytomas and some papillary tumors. No association was found between CD70 expression and stage or grade. High CD70 expression was associated with decreased survival on univariate analysis in the clear cell subset of RCC, however, it did not retain significance on multi-variable analysis. Given the elevated expression of CD70 in clear cell, sarcomatoid, and some papillary tumors, our findings suggest that CD70 might be a good drug target in RCC. Additional studies are warranted to assess the association between expression of CD70 and response to therapy with CD70 targeting drugs in RCC.
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