Defective homocysteine metabolism as a risk factor for diabetic retinopathy
Defective homocysteine metabolism as a risk factor for diabetic retinopathy
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DOI：
10.1016/s0140-6736(05)61185-3
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发表时间：
1997-02-15
期刊：
影响因子：
168.9
通讯作者：
Wantanabe, T
中科院分区：
文献类型：
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作者：
Neugebauer, S;Baba, T;Wantanabe, T
Ekbom和他的同事报告说，出生前接触麻疹和晚年克罗恩病之间显然存在很强的联系。1我们最近完成了对3076名在怀孕期间暴露于包括麻疹在内的病毒疾病的人的跟踪调查，以及3076名未被如此暴露的人，他们在性别、出生日期和出生地区方面匹配。这个名为国家统计办公室研究MR10的样本是在20世纪80年代初收集的，目的是调查病毒感染在子宫内的长期影响。2最近一次随访是在1994-96年间，当时参与者的年龄为16-53岁，使用的方法与最初的研究类似。在NHS中央登记处确定了人们的身份后，向全科医生发送了关于终生发病率的问卷(包括关于炎症性肠病发生的问题)。从业者没有被告知患者的暴露状况。研究样本自一开始就收集了死亡证明。临床信息按ICD-9进行编码。47人被杀
Ekbom and colleagues report an apparently strong association between prenatal exposure to measles and Crohn’s disease in later life. 1 We have recently completed a follow-up of 3076 people exposed to viral illnesses, including measles, during gestation, and 3076 not known to have been so exposed, matched on sex, birth date, and area of birth. This sample, Office of National Statistics study MR10, was assembled in the early 1980s to investigate the long-term effects of viral infections in utero. 2 The latest follow-up was during 1994–96, when the participants were aged 16–53, and used methods similar to those in the original study. After identification of people in the NHS Central Register, questionnaires concerning lifelong morbidity (including a question on the occurrence of inflammatory bowel disease) were sent to general practitioners. Practitioners were not informed of the exposure status of the patients. Death certificates had been collected on the study sample since its inception. Clinical information was coded according to ICD-9. 47 people were