Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction
Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction
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DOI：
10.1210/jc.2005-0576
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发表时间：
2005-09-01
影响因子：
5.8
通讯作者：
Ordovas, JM
中科院分区：
文献类型：
--
作者：
Corella, D;Qi, L;Ordovas, JM
背景：如果可以获得有关个体对饮食的遗传反应的预测信息，则可以改善肥胖症的饮食治疗。脂肪组织一直是鉴定候选基因的工作重点。 Perilipin 是脂肪细胞中发现的主要蛋白质，Perilipin 基因敲除小鼠体形苗条，对饮食诱导的肥胖有抵抗力。 目的：本研究的目的是检查 Perilipin (PLIN) 基因座的几种多态性与肥胖和肥胖患者低能量饮食导致的体重减轻之间的关联。 设计：本研究是一项为期 1 年的随机（取决于 PLIN 基因型）试验，包含 3 项后续评估。 背景：该研究于某大学研究中心。 受试者： 150 名基线肥胖患者（体重指数，42 +/- 8 kg/m(2)）和 48 名完成减肥饮食后续治疗的患者参与了这项研究。 干预措施： 受试者完成了为期 1 年的低能量饮食。主要结果测量：测量基线以及 3、6 和 12 个月时的体重 (BW)。结果：PLIN 11482G > A 的次要 A 等位基因 > A 多态性与较低基线 BW 相关。此外，我们发现这种多态性与完成一年饮食治疗的患者体重减轻之间存在基因-饮食相互作用（P = 0.015）。饮食导致 GG 患者 (n = 33) 的体重显着下降（从基线时的 114.3 +/- 3.9 kg 降至 1 年时的 105.5 +/- 3.5 kg；P 线性趋势，0.020）。相反，次要 A 等位基因携带者 (n = 15) 的体重没有显着变化（从基线时的 105.0 +/- 4.6 kg 到 1 年时的 104.3 +/- 4.4 kg；P 线性趋势，0.985）。即使在调整基线体重差异和其他潜在混杂因素后，这种基因-饮食相互作用仍然具有统计学意义。结论：PLIN11482A 携带者对体重减轻有抵抗力，表明这种多态性可以预测基于低能量饮食的体重减少策略的结果。
Context: Dietary treatment of obesity could be improved if predictive information about the individual's genetic response to diet was available. Adipose tissue has been the focus of efforts to identify candidate genes. Perilipin is a major protein found in adipocytes, and perilipin knockout mice are lean and resistant to diet-induced obesity.Objective: The objective of the study was to examine the association of several polymorphisms at the perilipin (PLIN) locus with obesity and weight reduction in response to a low-energy diet in obese patients.Design: This study was a 1-yr randomized (depending on the PLIN genotype) trial with three follow-up evaluations.Setting: The study was conducted at a university research center.Subjects: One hundred fifty obese patients (body mass index, 42 +/- 8 kg/m(2)) at baseline and 48 patients who completed the dietary follow-up treatment for weight loss participated in the study.Interventions: Subjects completed a 1-yr low-energy diet. Main Outcomes Measurements: Body weight (BW) at baseline and 3, 6, and 12 months was measured.Results: The minor A-allele at the PLIN 11482G > A polymorphism was associated with lower baseline BW. Moreover, we found a gene-diet interaction (P = 0.015) between this polymorphism and weight loss in patients that completed the 1-yr dietary treatment. Diet resulted in significant decreases in BW (from 114.3 +/- 3.9 kg at baseline to 105.5 +/- 3.5 kg at 1 yr; P lineal trend, 0.020) in GG patients (n = 33). Conversely, carriers of the minor A allele (n = 15) did not show significant changes in BW (from 105.0 +/- 4.6 kg at baseline to 104.3 +/- 4.4 kg at 1 yr; P lineal trend, 0.985). This gene- diet interaction remained statistically significant, even after adjustment for differences in BW at baseline and for other potential confounders.Conclusions: PLIN11482A carriers were resistant to weight loss, suggesting that this polymorphism may predict outcome of BW reduction strategies based on low-energy diets.