Noninvasive scintigraphic method to quantify unstimulated secretions from individual salivary glands.
Noninvasive scintigraphic method to quantify unstimulated secretions from individual salivary glands.
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DOI：
10.1016/s0385-8146(99)00026-7
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发表时间：
1999-10-01
期刊：
影响因子：
--
通讯作者：
Samuel, A M
中科院分区：
文献类型：
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作者：
Malpani, B L;Jaiswar, R K;Samuel, A M
目得：历史上，唾液腺的功能与口腔卫生的维持有关。腮腺和下颌下腺分泌行为的差异先前已被证明。本研究的目的是建立一种基于示踪输出理论的非侵入性技术来定量非刺激（静息状态）唾液分泌。对时间活性曲线进行两步背景扣除方案（面积归一化背景扣除，然后是用于背景校正的图形方法）。将个体唾液腺建模为器官曲线=输入-输出。从这些摄取率和未受刺激的唾液腺部分输出率（FOR）计算。主要结果：腮腺以及颌下腺有相同的示踪剂摄取率。与腮腺相比，下颌下腺中观察到一种独特的模式。颌下腺未受刺激的分泌物总量呈稳定上升趋势。下颌下腺的FOR是腮腺的3倍左右（P< 0.000001）。所观察到的分布的腮腺和下颌下腺的FOR显示，腮腺-FOR通常是在较低的一侧，而下下颌骨-FOR表现出广泛的分布，这是多模式的natural.Principal结论：一个独特的方法已经提出了量化的非刺激性唾液分泌。该方法简单且无创。
PURPOSE: Historically salivary gland function has been associated with maintenance of oral hygiene The difference in secretory behavior of parotid and submandibular glands has previously been shown. The purpose of this study was to establish a noninvasive technique for quantification of unstimulated (resting state) secretion of saliva based on the tracer output theory.PROCEDURES: A total of 14 99mTc-pertechnetate salivary function studies were performed under Gamma camera. The time activity curves were subjected to a two step background subtraction protocol (area normalised background subtraction, followed by a graphical method for background correction). Individual salivary glands were modeled as Organ Curve = Input - Output. From these Uptake rates and unstimulated salivary gland fractional output rates (FOR) were calculated.MAIN RESULTS: Parotid as well as submandibular glands have identical Uptake rates for the tracer. A distinct pattern was noted in submandibular glands as against parotid glands. Submandibular glands showed a steady rise in total quantity of unstimulated secretion. The FOR for submandibular glands was about three times higher than parotid glands (P< 0.000001). The observed distribution of FOR for parotid and submandibular glands FOR showed that parotid-FOR was normally on the lower side whereas submandibular-FOR showed a wide range of distribution which was multimodal in nature.PRINCIPAL CONCLUSION: A unique approach has been presented for quantification of unstimulated salivary secretion. The method is simple and noninvasive.